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Lung Function Decline in Relation to COVID-19 in the General Population: A Matched Cohort Study With Prepandemic Assessment of Lung Function.
Iversen, Katrine K; Afzal, Shoaib; Ahlström, Magnus G; Nordestgaard, Børge G; Schneider, Uffe V; Nielsen, Lene; Kofoed, Klaus; Benfield, Thomas; Ronit, Andreas.
  • Iversen KK; Department of Infectious Diseases 144, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark.
  • Afzal S; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Ahlström MG; The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Nordestgaard BG; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Schneider UV; Department of Clinical Microbiology, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
  • Nielsen L; Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Kofoed K; The Copenhagen General Population Study, Copenhagen University Hospital-Herlev and Gentofte, Herlev, Denmark.
  • Benfield T; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Ronit A; Department of Clinical Microbiology, Copenhagen University Hospital-Amager Hvidovre, Hvidovre, Denmark.
J Infect Dis ; 225(8): 1308-1316, 2022 04 19.
Article in English | MEDLINE | ID: covidwho-1705456
ABSTRACT

BACKGROUND:

To quantify the potential decline in dynamic lung volumes following coronavirus disease 2019 (COVID-19) in the general population.

METHODS:

A prospective matched cohort study of adult Copenhagen General Population Study (CGPS) participants with a prepandemic spirometry available. CGPS individuals with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) polymerase chain reaction (PCR) test performed repeat spirometry, a questionnaire regarding respiratory symptoms, and diffusing capacity test for carbon monoxide. A matched uninfected CGPS control sample was used, and simple regression and linear mixed effect models were computed to study lung function decline.

RESULTS:

A total of 606 individuals were included; 92/107 (85.9%) with positive SARS-CoV-2 PCR test experienced coronavirus disease 2019 (COVID-19) symptoms and 12 (11.2%) were hospitalized. Spirometry was performed at median 5.6 months (interquartile range, 3.9-12.8) after positive SARS-CoV-2 PCR test. COVID-19 was associated with adjusted 7.3 mL (95% confidence interval [CI], .3-14.3) and 22.6 mL (95% CI, 13.1-32.0) steeper decline in annual forced expiratory volume in first second (FEV1) and FVC or total 113.8 and 301.3 mL lower FEV1 and FVC from baseline to follow-up. Results were robust in analyses restricted to individuals not requiring hospitalization.

CONCLUSIONS:

COVID-19-related declines of dynamic lung volume in the general population not requiring hospitalization were small but measurable.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis