Long-Term Sequelae of COVID-19: A Systematic Review and Meta-Analysis of One-Year Follow-Up Studies on Post-COVID Symptoms.
Pathogens
; 11(2)2022 Feb 19.
Article
in English
| MEDLINE | ID: covidwho-1705975
ABSTRACT
Emerging evidence has shown that COVID-19 survivors could suffer from persistent symptoms. However, it remains unclear whether these symptoms persist over the longer term. This study aimed to systematically synthesise evidence on post-COVID symptoms persisting for at least 12 months. We searched PubMed and Embase for papers reporting at least one-year follow-up results of COVID-19 survivors published by 6 November 2021. Random-effects meta-analyses were conducted to estimate pooled prevalence of specific post-COVID symptoms. Eighteen papers that reported one-year follow-up data from 8591 COVID-19 survivors were included. Fatigue/weakness (28%, 95% CI 18-39), dyspnoea (18%, 95% CI 13-24), arthromyalgia (26%, 95% CI 8-44), depression (23%, 95% CI 12-34), anxiety (22%, 95% CI 15-29), memory loss (19%, 95% CI 7-31), concentration difficulties (18%, 95% CI 2-35), and insomnia (12%, 95% CI 7-17) were the most prevalent symptoms at one-year follow-up. Existing evidence suggested that female patients and those with more severe initial illness were more likely to suffer from the sequelae after one year. This study demonstrated that a sizeable proportion of COVID-19 survivors still experience residual symptoms involving various body systems one year later. There is an urgent need for elucidating the pathophysiologic mechanisms and developing and testing targeted interventions for long-COVID patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Pathogens11020269
Similar
MEDLINE
...
LILACS
LIS