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COVID-19 Course in Allergic Asthma Patients: A Spanish Cohort Analysis.
Habernau Mena, Alicia; García-Moguel, Ismael; Vazquez de la Torre Gaspar, María; Mugica, Victoria; Alvarado Izquierdo, Maria Isabel; Jimenez Blanco, Maria Aranzazu; Gandolfo-Cano, Mar; Jiménez Lara, Mar; Gonzalez Moreno, Ana; Saura Foix, Pilar; Navarro-Pulido, Ana; Martin-Arriscado Arroba, Cristina; Delgado Romero, Julio; Dominguez-Ortega, Javier.
  • Habernau Mena A; Department of Allergy. Complejo Hospitalario de Mérida, Mérida, Spain.
  • García-Moguel I; Department of Allergy, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Vazquez de la Torre Gaspar M; Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas 12), Madrid, Spain.
  • Mugica V; Department of Allergy, Hospital Universitario Infanta Leonor, Madrid, Spain.
  • Alvarado Izquierdo MI; Department of Allergy, Hospital de la Princesa, Madrid, Spain.
  • Jimenez Blanco MA; Department of Allergy, Hospital Universitario de Cáceres, Cáceres, Spain.
  • Gandolfo-Cano M; Department of Allergy, Hospital Cruz Roja, Madrid, Spain.
  • Jiménez Lara M; Department of Allergy, Hospital Universitario de Fuenlabrada, Madrid, Spain.
  • Gonzalez Moreno A; Department of Allergy, Hospital de Toledo, Toledo, Spain.
  • Saura Foix P; Department of Allergy, Fundación Hospital Alcorcón, Madrid, Spain.
  • Navarro-Pulido A; Department of Allergy, Consorci Sanitari de Terrassa, Terrassa, Spain.
  • Martin-Arriscado Arroba C; Allergology Clinical Management Unit (UGC), El Tomillar Hospital, Sevilla, Spain.
  • Delgado Romero J; Research and Science Support Unit, Instituto de investigación Biomédica del Hospital Universitario 12 de Octubre I+12, Madrid, Spain.
  • Dominguez-Ortega J; Department of Allergy, Hospital Universitario Virgen Macarena, Sevilla, Spain.
J Asthma Allergy ; 15: 257-264, 2022.
Article in English | MEDLINE | ID: covidwho-1706061
ABSTRACT

PURPOSE:

The acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has had a high impact on patients with chronic diseases. In the literature, there are different perspectives on asthma as comorbidity or risk factor on COVID-19 severity. PATIENTS AND

METHODS:

The aim of this retrospective study across 13 allergy departments in Spain was to determine the severity of COVID-19 in asthmatic adults followed in allergy departments and its relationship with atopy, clinical and demographic characteristics, phenotypes and laboratory data. In addition, lung function test and asthma control test (ACT) before and after COVID-19 were analyzed. Data was obtained from electronic medical records from March 2020 to April 2021.

RESULTS:

Two hundred one asthmatic patients were diagnosed with COVID-19 infection by validated detection test. About 30% of the patients were admitted for bilateral pneumonia. Advanced age, elevated D-dimer, lower numbers of lymphocytes and eosinophils, heart diseases and hypertension were associated with severe COVID-19. Allergic and mixed allergic/eosinophilic phenotype and their biomarkers (total IgE, aeroallergens sensitizations, allergic rhinitis, and blood eosinophilia) were related to fewer hospital admissions. Poor control and lower forced expiratory volume in the first second (FEV1) were related to worse prognosis of COVID-19.

CONCLUSION:

Asthmatic patients with allergic and eosinophilic phenotype have a better evolution of COVID-19 and lower risk of admissions. Older patients, cardiovascular comorbidities, AERD and eosinopenia are related to severity COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Asthma Allergy Year: 2022 Document Type: Article Affiliation country: JAA.S344934

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Language: English Journal: J Asthma Allergy Year: 2022 Document Type: Article Affiliation country: JAA.S344934