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Assessment of Sudden Sensorineural Hearing Loss After COVID-19 Vaccination.
Formeister, Eric J; Wu, Matthew J; Chari, Divya A; Meek, Robert; Rauch, Steven D; Remenschneider, Aaron K; Quesnel, Alicia M; de Venecia, Ronald; Lee, Daniel J; Chien, Wade; Stewart, C Matthew; Galaiya, Deepa; Kozin, Elliott D; Sun, Daniel Q.
  • Formeister EJ; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Wu MJ; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • Chari DA; Department of Otolaryngology-Head and Neck Surgery, University of Massachusetts School of Medicine, Worcester, Massachusetts.
  • Meek R; Anne Arundel Ear, Nose, and Throat Surgery, Annapolis, Maryland.
  • Rauch SD; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • Remenschneider AK; Department of Otolaryngology-Head and Neck Surgery, University of Massachusetts School of Medicine, Worcester, Massachusetts.
  • Quesnel AM; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • de Venecia R; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • Lee DJ; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • Chien W; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Stewart CM; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Galaiya D; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
  • Kozin ED; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts.
  • Sun DQ; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
JAMA Otolaryngol Head Neck Surg ; 148(4): 307-315, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1706644
ABSTRACT
IMPORTANCE Emerging reports of sudden sensorineural hearing loss (SSNHL) after COVID-19 vaccination within the otolaryngological community and the public have raised concern about a possible association between COVID-19 vaccination and the development of SSNHL.

OBJECTIVE:

To examine the potential association between COVID-19 vaccination and SSNHL. DESIGN, SETTING, AND

PARTICIPANTS:

This cross-sectional study and case series involved an up-to-date population-based analysis of 555 incident reports of probable SSNHL in the Centers for Disease Control and Prevention Vaccine Adverse Events Reporting System (VAERS) over the first 7 months of the US vaccination campaign (December 14, 2020, through July 16, 2021). In addition, data from a multi-institutional retrospective case series of 21 patients who developed SSNHL after COVID-19 vaccination were analyzed. The study included all adults experiencing SSNHL within 3 weeks of COVID-19 vaccination who submitted reports to VAERS and consecutive adult patients presenting to 2 tertiary care centers and 1 community practice in the US who were diagnosed with SSNHL within 3 weeks of COVID-19 vaccination. EXPOSURES Receipt of a COVID-19 vaccine produced by any of the 3 vaccine manufacturers (Pfizer-BioNTech, Moderna, or Janssen/Johnson & Johnson) used in the US. MAIN OUTCOMES AND

MEASURES:

Incidence of reports of SSNHL after COVID-19 vaccination recorded in VAERS and clinical characteristics of adult patients presenting with SSNHL after COVID-19 vaccination.

RESULTS:

A total of 555 incident reports in VAERS (mean patient age, 54 years [range, 15-93 years]; 305 women [55.0%]; data on race and ethnicity not available in VAERS) met the definition of probable SSNHL (mean time to onset, 6 days [range, 0-21 days]) over the period investigated, representing an annualized incidence estimate of 0.6 to 28.0 cases of SSNHL per 100 000 people per year. The rate of incident reports of SSNHL was similar across all 3 vaccine manufacturers (0.16 cases per 100 000 doses for both Pfizer-BioNTech and Moderna vaccines, and 0.22 cases per 100 000 doses for Janssen/Johnson & Johnson vaccine). The case series included 21 patients (mean age, 61 years [range, 23-92 years]; 13 women [61.9%]) with SSNHL, with a mean time to onset of 6 days (range, 0-15 days). Patients were heterogeneous with respect to clinical and demographic characteristics. Preexisting autoimmune disease was present in 6 patients (28.6%). Of the 14 patients with posttreatment audiometric data, 8 (57.1%) experienced improvement after receiving treatment. One patient experienced SSNHL 14 days after receiving each dose of the Pfizer-BioNTech vaccine. CONCLUSIONS AND RELEVANCE In this cross-sectional study, findings from an updated analysis of VAERS data and a case series of patients who experienced SSNHL after COVID-19 vaccination did not suggest an association between COVID-19 vaccination and an increased incidence of hearing loss compared with the expected incidence in the general population.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Hearing Loss, Sudden / COVID-19 / Hearing Loss, Sensorineural Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: JAMA Otolaryngol Head Neck Surg Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines / Hearing Loss, Sudden / COVID-19 / Hearing Loss, Sensorineural Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: JAMA Otolaryngol Head Neck Surg Year: 2022 Document Type: Article