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Rapidly Increasing Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Intravenous Immunoglobulins Produced From Plasma Collected During the 2020 Pandemic.
Farcet, Maria R; Karbiener, Michael; Schwaiger, Julia; Ilk, Reinhard; Kreil, Thomas R.
  • Farcet MR; Global Pathogen Safety, Baxter AG (part of Takeda), Vienna, Austria.
  • Karbiener M; Global Pathogen Safety, Baxter AG (part of Takeda), Vienna, Austria.
  • Schwaiger J; Global Pathogen Safety, Baxter AG (part of Takeda), Vienna, Austria.
  • Ilk R; Global Manufacturing Sciences, Baxter AG (part of Takeda), Vienna, Austria.
  • Kreil TR; Global Pathogen Safety, Baxter AG (part of Takeda), Vienna, Austria.
J Infect Dis ; 226(8): 1357-1361, 2022 10 17.
Article in English | MEDLINE | ID: covidwho-1706826
ABSTRACT
Immunoglobulin lots (N = 176) released since March 2020 were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies, with first positive results for September 2020 lots (mean, 1.7 IU/mL; 46% of lots positive). From there, values steadily increased, in correlation with the cumulative coronavirus disease 2019 (COVID-19) incidence, to reach a mean of 31.2 IU/mL and 93% of lots positive by January 2021. Extrapolating the correlation, immunoglobulins could reach an anti-SARS-CoV-2 potency of approximately 345 IU/mL by July 2021. At that stage, prophylactic immunoglobulin treatment for primary/secondary immunodeficiency could contain similar doses of anti-SARS-CoV-2 as convalescent plasma that is used for treatment of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Observational study Limits: Humans Language: English Journal: J Infect Dis Year: 2022 Document Type: Article Affiliation country: Infdis