Relationship Between COVID-19 Lockdown and Epidemiology of Neonatal Sepsis.
Pediatr Infect Dis J
; 41(6): 482-489, 2022 06 01.
Article
in English
| MEDLINE | ID: covidwho-1707086
ABSTRACT
BACKGROUND:
We compared the hospital-based epidemiology of neonatal sepsis after the coronavirus disease 2019 lockdown (LD) versus historical epochs and the LD period versus phases of unlocking.METHODS:
This retrospective cohort study was conducted in a level 3 neonatal unit. We compared neonates born in three 24-week periods-Group LD 22 March 2020 to 5 September 2020-the reference group, Group pre-LD 29 September 2019 to 14 March 2020 and Group temporally corresponding to LD in 2019 (corres-LD) 24 March 2019 to 7 September 2019. We also studied linear trends from LD phase 1.0 until Unlock 4.0. The key outcome was culture-positive sepsis.RESULTS:
There were 1622, 2744 and 2700 subjects in groups LD, pre-LD and corres-LD, respectively. The incidence of any culture-positive sepsis in pre-LD was higher than LD [odds ratio (95% CI) = 1.61 (1.02-2.56)]. This was mainly due to a statistically significant reduction in Acinetobacter baumannii sepsis, with incidence rate differences of pre-LD versus LD [0.67 (95% CI 0.37-0.97), P = 0.0001] and corres-LD versus LD [0.40 (95% CI 0.16-0.64), P = 0.0024]. Groups pre-LD and corres-LD had higher proportion of multi-drug resistant (MDR)/extreme drug resistance/pan drug resistance sepsis than LD [77%, 77% and 44%, respectively (P values of both groups vs. LD = 0.01)]. From LD 1.0 to unlock 4.0, there were fewer episodes of MDR sepsis (Plinear trends = 0.047). On multivariable analysis, group pre-LD (vs. reference group LD), male sex, birth weight and Apgar score independently predicted culture-positive sepsis.CONCLUSIONS:
LD favorably impacted the epidemiology of neonatal sepsis in a hospital setting, with less A. baumannii and MDR sepsis, which persisted during unlocking.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sepsis
/
Neonatal Sepsis
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Humans
/
Male
/
Infant, Newborn
Language:
English
Journal:
Pediatr Infect Dis J
Journal subject:
Communicable Diseases
/
Pediatrics
Year:
2022
Document Type:
Article
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