Update on Phototherapy and Childhood Cancer in a Northern California Cohort.
Pediatrics
; 148(5)2021 11.
Article
in English
| MEDLINE | ID: covidwho-1707239
ABSTRACT
OBJECTIVES:
We aimed to reassess the relationship between phototherapy and cancer in an extended version of a previous cohort and to replicate a report from Quebec of increased cancer risk after phototherapy beginning at age 4 years.METHODS:
This cohort study included 139 100 children born at ≥35 weeks' gestation from 1995 to 2017, followed through March 16, 2019, in Kaiser Permanente Northern California hospitals who had a qualifying bilirubin level from -3 mg/dL to +4.9 mg/dL from the American Academy of Pediatrics phototherapy threshold; an additional 40 780 children and 5 years of follow-up from our previous report. The exposure was inpatient phototherapy (yes or no), and the outcomes were various types of childhood cancer. We used Cox proportional hazard models, controlling for propensity-score quintiles, and allowed for time-dependent exposure effects to assess for the risk of cancer after a latent period.RESULTS:
Over a mean (SD) follow-up of 8.2 (5.7) years, the crude incidence of cancer per 100 000 person-years was 25.1 among those exposed to phototherapy and 19.2 among those not exposed (233 cases of cancer). After propensity adjustment, phototherapy was not associated with any cancer (hazard ratio [HR] 1.13, 95% confidence interval [CI] 0.83-1.54), hematopoietic cancer (HR 1.17, 95% CI 0.74-1.83), or solid tumors (HR 1.01, 95% CI 0.65-1.58). We also found no association with cancer diagnoses at age ≥4 years.CONCLUSIONS:
We did not confirm previous, concerning associations between phototherapy and adjusted risk of any cancer, nonlymphocytic leukemia, or brain and/or central nervous systems tumors in later childhood.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Phototherapy
/
Neoplasms
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
North America
Language:
English
Year:
2021
Document Type:
Article
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