Predictive Value of Myocardial injury in Patients with COVID-19 Admitted to a Quaternary Hospital in the City of Rio de Janeiro
COVID-19 Mortality Myocardial, Contusions SARS-CoV-2 Troponin, I
; 2022(International Journal of Cardiovascular Sciences)
Article
in English
| WHO COVID | ID: covidwho-1707549
ABSTRACT
Background:
In Brazil the factors involved in the risk of death in patients with COVID-19 have not been well established.Objective:
To analyze whether elevations of high-sensitivity troponin I (hTnI) levels influence the mortality of patients with COVID-19.Methods:
Clinical and laboratory characteristics of hospitalized patients with COVID-19 were collected upon hospital admission. Univariate and binary logistic regression analyzes were performed to assess the factors that influence mortality. P-value<0.05 was considered significant.Results:
This study analyzed192 patients who received hospital admission between March 16 and June 2, 2020 and who were discharged or died by July 2, 2020. The mean age was 70±15 years, 80 (41.7%) of whom were women. In comparison to those who were discharged, the 54 (28.1%) who died were older (79±12 vs 66±15years;P=0.004), and with a higher Charlson´s index (5±2 vs 3±2;P=0.027). More patients, aged≥60years (P <0.0001), Charlson´s index>1 (P=0.004), lung injury>50% in chest computed tomography (P=0.011), with previous coronary artery disease (P=0.037), hypertension (P=0.033), stroke (P=0.008), heart failure (P=0.002), lymphocytopenia (P=0.024), high D-dimer (P=0.024), high INR (P=0.003), hTnI (P<0.0001), high creatinine (P<0.0001), invasive mechanical ventilation (P<0.0001), renal replacement therapy (P<0.0001), vasoactive amine (P<0.0001), and transfer to the ICU (P=0.001), died when compared to those who were discharged. In logistic regression analysis, elevated hTnI levels (OR=9.504;95% CI=1.281–70.528;P=0.028) upon admission, and the need for mechanical ventilation during hospitalization (OR=46.691;95% CI=2.360–923.706;P=0.012) increased the chance of in-hospital mortality.Conclusion:
This study suggests that in COVID-19 disease, myocardial injury upon hospital admission is a harbinger of poor prognosis. © 2022, Arquivos Brasileiros de Cardiologia. All rights reserved.
Full text:
Available
Collection:
Databases of international organizations
Database:
WHO COVID
Type of study:
Prognostic study
Language:
English
Journal:
COVID-19 Mortality Myocardial, Contusions SARS-CoV-2 Troponin, I
Document Type:
Article
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