An old problem with new solutions: Strategies to improve vaccine efficacy in the elderly.
Adv Drug Deliv Rev
; 183: 114175, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1708738
ABSTRACT
Vaccination is the most effective measure to protect against infections. However, with increasing age, there is a progressive decline in the ability of the immune system to both protect against infection and develop protective immunity from vaccination. This age-related decline of the immune system is due to age-related changes in both the innate and adaptive immune systems. With an aging world population and increased risk of pandemics, there is a need to continue to develop strategies to increase vaccine responses in the elderly. Here, the major age-related changes that occur in both the innate and adaptive immune responses that impair the response to vaccination in the elderly will be highlighted. Existing and future strategies to improve vaccine efficacy in the elderly will then be discussed, including adjuvants, delivery methods, and formulation. These strategies provide mechanisms to improve the efficacy of existing vaccines and develop novel vaccines for the elderly.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aging
/
Vaccine Efficacy
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Aged
/
Animals
/
Humans
Language:
English
Journal:
Adv Drug Deliv Rev
Journal subject:
Pharmacology
/
Drug Therapy
Year:
2022
Document Type:
Article
Affiliation country:
J.addr.2022.114175
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