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Pericarditis and myocarditis after COVID-19 mRNA vaccination in a nationwide setting
Ann Acad Med Singap ; 51(2):96-100, 2022.
Article in English | PubMed | ID: covidwho-1711094
ABSTRACT

INTRODUCTION:

Despite reports suggesting an association between COVID-19 mRNA vaccination and pericarditis and myocarditis, detailed nationwide population-based data are sparsely available. We describe the incidence of pericarditis and myocarditis by age categories and sex after COVID-19 mRNA vaccination from a nationwide mass vaccination programme in Singapore.

METHODS:

The incidence of adjudicated cases of pericarditis and myocarditis following COVID-19 mRNA vaccination that were reported to the vaccine safety committee between January to July 2021 was compared with the background incidence of myocarditis in Singapore.

RESULTS:

As of end July 2021, a total of 34 cases were reported (9 pericarditis only, 14 myocarditis only, and 11 concomitant pericarditis and myocarditis) with 7,183,889 doses of COVID-19 mRNA vaccine administered. Of the 9 cases of pericarditis only, all were male except one. The highest incidence of pericarditis was in males aged 12-19 years with an incidence of 1.11 cases per 100,000 doses. Of the 25 cases of myocarditis, 80% (20 cases) were male and the median age was 23 years (range 12-55 years) with 16 cases after the second dose. A higher-than-expected number of cases were seen in males aged 12-19 and 20-29 years, with incidence rates of 3.72 and 0.98 case per 100,000 doses, respectively.

CONCLUSION:

Data from the national registry in Singapore indicate an increased incidence of pericarditis and myocarditis in younger men after COVID-19 mRNA vaccination.
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Collection: Databases of international organizations Database: PubMed Topics: Vaccines Language: English Journal: Ann Acad Med Singap Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: PubMed Topics: Vaccines Language: English Journal: Ann Acad Med Singap Year: 2022 Document Type: Article