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Disease severity and renal outcomes of patients with chronic kidney disease infected with COVID-19.
Gur, Efrat; Levy, David; Topaz, Guy; Naser, Rawand; Wand, Ori; Kitay-Cohen, Yona; Benchetrit, Sydney; Sarel, Erez; Cohen-Hagai, Keren.
  • Gur E; Department of Internal Medicine C, Meir Medical Center, Kefar Sava, Israel.
  • Levy D; Department of Internal Medicine C, Meir Medical Center, Kefar Sava, Israel.
  • Topaz G; Department of Internal Medicine C, Meir Medical Center, Kefar Sava, Israel.
  • Naser R; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Wand O; Department of Internal Medicine C, Meir Medical Center, Kefar Sava, Israel.
  • Kitay-Cohen Y; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Benchetrit S; Department of Pulmonology, Meir Medical Center, Kefar Sava, Israel.
  • Sarel E; Department of Internal Medicine C, Meir Medical Center, Kefar Sava, Israel.
  • Cohen-Hagai K; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Clin Exp Nephrol ; 26(5): 445-452, 2022 May.
Article in English | MEDLINE | ID: covidwho-1712257
ABSTRACT

INTRODUCTION:

While there is evidence of the presence of the coronavirus in the kidneys and resultant acute kidney injury (AKI), information on the effect of chronic kidney disease (CKD) on COVID-19 outcomes and its pathogenesis is currently lacking.

METHODS:

This retrospective, observational study evaluated the outcomes of all consecutive patients hospitalized during COVID-19 outbreaks in Meir Medical Center. Serum creatinine level was assessed before hospitalization ("baseline serum creatinine") and at admission, as well as minimum and maximum serum creatinine levels during hospitalization.

RESULTS:

Among 658 patients, 152 had eGFR < 60 ml/min (termed the CKD group), 506 patients served as controls. Patients in the CKD group were older, with higher prevalence of hypertension, diabetes mellitus and atherosclerosis. Disease severity and clinical presentation of CKD group were comparable to that of control group. Odds ratio for AKI was 5.8 (95%CI 3.8-8.7; p < 0.001) in CKD group vs. control group and 3.4 (95%CI 1.1-10.8) for renal replacement therapy (p < 0.026). Among the CKD group, 32.2% died after COVID-19 infection versus 14.8% of the controls (p < 0.001). Mortality increased as CKD stage increased (14.8% in controls, 29.6% in CKD stage 3, and 39.3% in CKD stages 4 and 5, p < 0.001).

CONCLUSION:

Despite comparable disease severity at presentation, patients with CKD had significantly more AKI events and required more renal replacement therapy during hospitalization than control patients did. Mortality increased as CKD stage increased.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Clin Exp Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S10157-022-02180-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Clin Exp Nephrol Journal subject: Nephrology Year: 2022 Document Type: Article Affiliation country: S10157-022-02180-6