Metabolic programs tailor T cell immunity in viral infection, cancer, and aging.
Cell Metab
; 34(3): 378-395, 2022 03 01.
Article
in English
| MEDLINE | ID: covidwho-1712531
ABSTRACT
Productive T cell responses to infection and cancer rely on coordinated metabolic reprogramming and epigenetic remodeling among the immune cells. In particular, T cell effector and memory differentiation, exhaustion, and senescence/aging are tightly regulated by the metabolism-epigenetics axis. In this review, we summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states. We also discuss how the metabolic-epigenetic axis orchestrates T cell exhaustion and explore how physiological factors, such as diet, gut microbiota, and the circadian clock, are integrated in shaping T cell epigenetic modifications and functionality. Furthermore, we summarize key features of the senescent/aged T cells and discuss how to ameliorate vaccination- and COVID-induced T cell dysfunctions by metabolic modulations. An in-depth understanding of the unexplored links between cellular metabolism and epigenetic modifications in various physiological or pathological contexts has the potential to uncover novel therapeutic strategies for fine-tuning T cell immunity.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Virus Diseases
/
COVID-19
/
Neoplasms
Topics:
Vaccines
Limits:
Aged
/
Humans
Language:
English
Journal:
Cell Metab
Journal subject:
Metabolism
Year:
2022
Document Type:
Article
Affiliation country:
J.cmet.2022.02.003
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