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Metabolic programs tailor T cell immunity in viral infection, cancer, and aging.
Møller, Sofie Hedlund; Hsueh, Pei-Chun; Yu, Yi-Ru; Zhang, Lianjun; Ho, Ping-Chih.
  • Møller SH; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
  • Hsueh PC; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
  • Yu YR; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland. Electronic address: yi-ru.yu@unil.ch.
  • Zhang L; Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China; Suzhou Institute of Systems Medicine, Suzhou 215123, China. Electronic address: zlj@ism.cams.cn.
  • Ho PC; Department of Fundamental Oncology, University of Lausanne, Lausanne, Switzerland; Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland. Electronic address: ping-chih.ho@unil.ch.
Cell Metab ; 34(3): 378-395, 2022 03 01.
Article in English | MEDLINE | ID: covidwho-1712531
ABSTRACT
Productive T cell responses to infection and cancer rely on coordinated metabolic reprogramming and epigenetic remodeling among the immune cells. In particular, T cell effector and memory differentiation, exhaustion, and senescence/aging are tightly regulated by the metabolism-epigenetics axis. In this review, we summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states. We also discuss how the metabolic-epigenetic axis orchestrates T cell exhaustion and explore how physiological factors, such as diet, gut microbiota, and the circadian clock, are integrated in shaping T cell epigenetic modifications and functionality. Furthermore, we summarize key features of the senescent/agedcells and discuss how to ameliorate vaccination- and COVID-induced T cell dysfunctions by metabolic modulations. An in-depth understanding of the unexplored links between cellular metabolism and epigenetic modifications in various physiological or pathological contexts has the potential to uncover novel therapeutic strategies for fine-tuning T cell immunity.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / COVID-19 / Neoplasms Topics: Vaccines Limits: Aged / Humans Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: J.cmet.2022.02.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / COVID-19 / Neoplasms Topics: Vaccines Limits: Aged / Humans Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2022 Document Type: Article Affiliation country: J.cmet.2022.02.003