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Demographic and Clinical Factors Related to Severe COVID-19 Infection and Mortality in Patients With Schizophrenia.
Ekinci, Okan; Erkan Ekinci, Asli.
  • Ekinci O; Psychiatry Department, Usak University Medical Faculty, Usak, Turkey.
J Nerv Ment Dis ; 210(4): 257-263, 2022 04 01.
Article in English | MEDLINE | ID: covidwho-1713793
ABSTRACT
ABSTRACT We aimed to explore the prevalence and determinants of severe COVID-19 disease and mortality in patients with schizophrenia in this study. We conducted a retrospective observational study of 1620 patients with schizophrenia. Of the 1620 patients, 52 (3.2%) tested positive for SARS-CoV-19. Among SARS-CoV-2-positive patients, 40 patients were hospitalized, and 17 patients required intensive care unit admission due to COVID-19 (76.9% and 32.7%, respectively). Severe COVID-19 disease was noted in 17 patients (32.7%) requiring intubation. In the logistic regression analysis, antipsychotic dose, and comorbidity score were independently associated with a greater risk of severe COVID-19 disease in patients with schizophrenia. Our study suggests that factors such as age, sex, comorbidities, and a daily antipsychotic dose may have effects on the poor outcome of SARS-CoV-2 disease in schizophrenia patients. In addition, the current findings propose that mortality may be associated with an older age, comorbidity score, and a longer duration of psychiatric disease among the SARS-CoV-2-positive patients with schizophrenia. However, the findings of our study should be verified in prospective and larger sample studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophrenia / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Nerv Ment Dis Year: 2022 Document Type: Article Affiliation country: Nmd.0000000000001500

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Schizophrenia / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Language: English Journal: J Nerv Ment Dis Year: 2022 Document Type: Article Affiliation country: Nmd.0000000000001500