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DEPEND study protocol: early detection of patients with pancreatic cancer - a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as screening tools in high-risk individuals.
Afolabi, Paul Remi; McDonnell, Declan; Byrne, Christopher D; Wilding, Sam; Goss, Victoria; Walters, Jocelyn; Hamady, Zaed Z.
  • Afolabi PR; Human Development and Health, University of Southampton Faculty of Medicine, Southampton, UK.
  • McDonnell D; Southampton Centre for Biomedical Research Mass Spectrometry, NIHR Southampton Biomedical Research Centre, Southampton, UK.
  • Byrne CD; Human Development and Health, University of Southampton Faculty of Medicine, Southampton, UK.
  • Wilding S; Southampton Centre for Biomedical Research, NIHR Southampton Biomedical Research Centre, Southampton, UK.
  • Goss V; Human Development and Health, University of Southampton Faculty of Medicine, Southampton, UK.
  • Walters J; Southampton Centre for Biomedical Research, NIHR Southampton Biomedical Research Centre, Southampton, UK.
  • Hamady ZZ; Southampton Clinical Trials Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
BMJ Open ; 12(2): e057271, 2022 Feb 25.
Article in English | MEDLINE | ID: covidwho-1714416
ABSTRACT

INTRODUCTION:

Pancreatic cancer (PC) is the fifth leading cause of cancer-related death in the UK. The incidence of PC is increasing, with little or no improvement in overall survival and the best chance for long-term survival in patients with PC relies on early detection and surgical resection. In this study, we propose the use of a diagnostic algorithm that combines tests of pancreatic exocrine function (faecal elastase-1 (FE-1) test and the 13C-mixed triglyceride (13C-MTG) breath test) to identify patients with PC that urgently needs imaging studies. METHODS AND

ANALYSIS:

This prospective pilot (proof of concept) study will be carried out on 25 patients with resectable PC, 10 patients with chronic pancreatitis and 25 healthy volunteers. This study will construct a predictive algorithm for PC, using two tests of pancreatic exocrine function, FE-1 test and the 13C-MTG breath test. Continuous flow isotope ratio mass spectrometry in the 13C-MTG breath test will be used to analyse enriched 13CO2 in exhaled breath samples. The additional predictive benefit of other potential biomarkers of PC will also be considered. Potential biomarkers of PC showing abilities to discriminate between patients with PC from healthy subjects or patients with chronic pancreatitis will be selected by metabolomic analysis. ETHICS AND DISSEMINATION The study was approved by the North of Scotland Research and Ethics Committee on 1 October 2020 (reference 20/NS/0105, favourable opinion granted). The results will be disseminated in presentations at academic national/international conferences and publication in peer-review journals.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exocrine Pancreatic Insufficiency / Pancreatic Neoplasms / Pancreatitis, Chronic Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-057271

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Exocrine Pancreatic Insufficiency / Pancreatic Neoplasms / Pancreatitis, Chronic Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: BMJ Open Year: 2022 Document Type: Article Affiliation country: Bmjopen-2021-057271