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Effect of Curcumin in Experimental Pulmonary Tuberculosis: Antimycobacterial Activity in the Lungs and Anti-Inflammatory Effect in the Brain.
Lara-Espinosa, Jacqueline V; Arce-Aceves, María Fernanda; López-Torres, Manuel O; Lozano-Ordaz, Vasti; Mata-Espinosa, Dulce; Barrios-Payán, Jorge; Silva-Islas, Carlos Alfredo; Maldonado, Perla D; Marquina-Castillo, Brenda; Hernández-Pando, Rogelio.
  • Lara-Espinosa JV; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Arce-Aceves MF; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • López-Torres MO; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Lozano-Ordaz V; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Mata-Espinosa D; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Barrios-Payán J; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Silva-Islas CA; Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
  • Maldonado PD; Laboratorio de Patología Vascular Cerebral, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City 14269, Mexico.
  • Marquina-Castillo B; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
  • Hernández-Pando R; Sección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City 14080, Mexico.
Int J Mol Sci ; 23(4)2022 Feb 10.
Article in English | MEDLINE | ID: covidwho-1715394
ABSTRACT
Tuberculosis (TB) is one of the ten leading causes of death worldwide. Patients with TB have been observed to suffer from depression and anxiety linked to social variables. Previous experiments found that the substantial pulmonary inflammation associated with TB causes neuroinflammation, neuronal death, and behavioral impairments in the absence of brain infection. Curcumin (CUR) is a natural product with antioxidant, anti-inflammatory and antibacterial activities. In this work, we evaluated the CUR effect on the growth control of mycobacteria in the lungs and the anti-inflammatory effect in the brain using a model of progressive pulmonary TB in BALB/c mice infected with drug-sensitive mycobacteria (strain H37Rv). The results have shown that CUR decreased lung bacilli load and pneumonia of infected animals. Finally, CUR significantly decreased neuroinflammation (expression of TNFα, IFNγ and IL12) and slightly increased the levels of nuclear factor erythroid 2-related to factor 2 (Nrf2) and the brain-derived neurotrophic factor (BDNF) levels, improving behavioral status. These results suggest that CUR has a bactericidal effect and can control pulmonary mycobacterial infection and reduce neuroinflammation. It seems that CUR has a promising potential as adjuvant therapy in TB treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Tuberculosis, Pulmonary / Brain / Curcumin / Lung / Anti-Inflammatory Agents / Antitubercular Agents Type of study: Experimental Studies Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23041964

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tuberculosis / Tuberculosis, Pulmonary / Brain / Curcumin / Lung / Anti-Inflammatory Agents / Antitubercular Agents Type of study: Experimental Studies Limits: Animals Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23041964