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Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy.
Ostermeier, Brita; Soriano-Sarabia, Natalia; Maggirwar, Sanjay B.
  • Ostermeier B; Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.
  • Soriano-Sarabia N; Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.
  • Maggirwar SB; Department of Microbiology Immunology and Tropical Medicine, The George Washington University, 2300 I Street NW, Washington, DC 20037, USA.
Int J Mol Sci ; 23(4)2022 Feb 19.
Article in English | MEDLINE | ID: covidwho-1715402
ABSTRACT
Platelets, which are small anuclear cell fragments, play important roles in thrombosis and hemostasis, but also actively release factors that can both suppress and induce viral infections. Platelet-released factors include sCD40L, microvesicles (MVs), and alpha granules that have the capacity to exert either pro-inflammatory or anti-inflammatory effects depending on the virus. These factors are prime targets for use in extracellular vesicle (EV)-based therapy due to their ability to reduce viral infections and exert anti-inflammatory effects. While there are some studies regarding platelet microvesicle-based (PMV-based) therapy, there is still much to learn about PMVs before such therapy can be used. This review provides the background necessary to understand the roles of platelet-released factors, how these factors might be useful in PMV-based therapy, and a critical discussion of current knowledge of platelets and their role in viral diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Virus Diseases / Blood Coagulation Factors / Extracellular Vesicles Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23042321

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Platelets / Virus Diseases / Blood Coagulation Factors / Extracellular Vesicles Limits: Animals / Humans Language: English Year: 2022 Document Type: Article Affiliation country: Ijms23042321