Serum Albumin for Magnetic Nanoparticles Coating
Magnetochemistry
; 8(2):13, 2022.
Article
in English
| ProQuest Central | ID: covidwho-1715524
ABSTRACT
Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide nanoparticles have demonstrated a promising effect in various biomedical applications due to their high magnetic properties, large surface area, stability, and easy functionalization. However, colloidal stability, biocompatibility, and potential toxicity of MNPs in physiological environments are crucial for their in vivo application. In this context, many research articles focused on the possible procedures for MNPs coating to improve their physic-chemical and biological properties. This review highlights one viable fabrication strategy of biocompatible iron oxide nanoparticles using human serum albumin (HSA). HSA is mainly a transport protein with many functions in various fundamental processes. As it is one of the most abundant plasma proteins, not a single drug in the blood passes without its strength test. It influences the stability, pharmacokinetics, and biodistribution of different drug-delivery systems by binding or forming its protein corona on the surface. The development of albumin-based drug carriers is gaining increasing importance in the targeted delivery of cancer therapy. Considering this, HSA is a highly potential candidate for nanoparticles coating and theranostics area and can provide biocompatibility, prolonged blood circulation, and possibly resolve the drug-resistance cancer problem.
Chemistry; iron oxide nanoparticles; functionalization; coating; serum albumin; drug delivery; toxicity; biostability; Biocompatibility; Drug carriers; Plasma; Iron oxides; Magnetic properties; Nanoparticles; Binding sites; Fatty acids; Drugs; Amino acids; Biological properties; Antioxidants; Delivery systems; In vivo methods and tests; Blood circulation; Proteins; COVID-19; Medical science; Pharmacodynamics; Biomedical materials; Cancer; Magnetic resonance imaging; Drug delivery systems; Pharmacokinetics; Biomarkers; Ligands; Molecular weight; Chemical bonds; Surface stability; Coronaviruses; Hyperthermia
Full text:
Available
Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
Magnetochemistry
Year:
2022
Document Type:
Article
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