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Clinical and autoimmune characteristics of COVID-19 patients in a tertiary care centre: a cross-sectional study
National Journal of Medical Research ; 11(4):121-124, 2021.
Article in English | GIM | ID: covidwho-1717277
ABSTRACT

Introduction:

Since the end of 2019, the world is witnessing the emergence of the coronavirus disease 2019 (COVID-19) outbreak and pandemic caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This disease presented with a wide array of clinical, inflammatory and possible autoimmune manifestations. Currently, a very few data is available about the involvement of autoimmunity in patients affected by coronavirus disease 2019 (COVID-19).

Aim:

To find out the clinical and inflammatory status of COVID-19 patients and whether this disease (SARS-CoV-2) stimulates autoantibody production and contributes to autoimmunity activation.

Methodology:

A hospital based retrospective study conducted on 60 COVID-19 patients. All patients were clinically and radiologically evaluated and screened for common inflammatory markers and auto antibodies.

Result:

Patients included were 39 men (65%) and 21 women (35%). 33 patients were mild cases, 15 were moderate and 12 were severe cases with a mean age of 44.27. Fever and shortness of breath were the dominant symptoms;most patients had at least one coexisting disorder on admission;the most common characteristic on chest CT was groundglass opacity;the most common findings on laboratory measurements of inflammatory markers were elevated levels of CRP, LDH, ferritin and altered neutrophil lymphocyte ratio;and prevalence of autoantibodies, anti SSA/Ro antibody, anti SSB/La antibody, and antinuclear antibody was 20%, 10%, and 15%, respectively and Anti-TPO antibody was positive in 33.3% patients.
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Collection: Databases of international organizations Database: GIM Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: National Journal of Medical Research Year: 2021 Document Type: Article

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Collection: Databases of international organizations Database: GIM Type of study: Observational study / Prognostic study / Randomized controlled trials Language: English Journal: National Journal of Medical Research Year: 2021 Document Type: Article