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Persistence of sleep disturbance among post-COVID patients: Findings from a 2-month follow-up study in a Bangladeshi cohort.
Islam, Md Khairul; Molla, Md Maruf Ahmed; Hasan, Pratyay; Sharif, Md Mohiuddin; Hossain, Fahima Sharmin; Amin, Md Robed; Rahman, Md Ridwanur.
  • Islam MK; Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.
  • Molla MMA; Depatment of Virology, National Institute of Laboratory Medicine and Referral Center, Dhaka, Bangladesh.
  • Hasan P; Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.
  • Sharif MM; Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.
  • Hossain FS; Indoor Medical Officer, National Institute of Mental Health, Dhaka, Bangladesh.
  • Amin MR; Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.
  • Rahman MR; Director and Professor of Medicine, Non-Communicable Disease Control, DGHS, Mohakhali, Dhaka, Bangladesh.
J Med Virol ; 94(3): 971-978, 2022 03.
Article in English | MEDLINE | ID: covidwho-1718360
ABSTRACT
To evaluate the persistence and factors associated with sleep disturbances among COVID-19 patients with a history of sleep disturbances 2 months after discharge from the hospital. A total of 400 patients admitted at Dhaka Medical College Hospital during July and August were diagnosed as suffering from sleep disturbances during their hospital stay using a standardized scale. They were followed up 2 months later through telephone, and a total of 322 participants were interviewed (excluding 63 nonresponders and five deceased) regarding the persistence of disturbances in sleep through a structured questionnaire. Patient demographic, clinical, and epidemiological data including history regarding in-hospital sleep disturbance were retrieved from hospital treatment sheets. Results revealed, 35% of study participants (n = 113) were still experiencing symptoms of sleep disturbances during the interview by telephone. Age (p = 0.015), diabetes mellitus (relative risk [RR] 1.21; confidence interval [CI] 1.02-1.42, p = 0.022), on admission SPO2 (p = 0.009), C-reactive protein (CRP) (p = 0.025), serum ferritin (p = 0.014), and d-dimer (p = 0.030) were independently associated with sleep disturbances among participants (p < 0.05). Binary and fitting logistic regression through repeated K folds cross-validation revealed 1.65 (CI 1.02-2.66), 1.07 (CI 1.01-1.14), and 1.07 (CI 1.00-1.15) times higher odds of persistence of sleep disturbances among patients with diabetes mellitus, increased neutrophil, and lymphocyte percentages, respectively. Findings of this study need to be validated and patients should be further followed up with more in-depth studies conducted 6 or 12 months after initial infection, possibly with the help of higher sample size and in-person interview.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Wake Disorders / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27397

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sleep Wake Disorders / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Qualitative research / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27397