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SARS-CoV-2 AY.4.2 variant circulating in Italy: Genomic preliminary insight.
Angeletti, Silvia; Giovanetti, Marta; Fogolari, Marta; Cella, Eleonora; De Florio, Lucia; Lintas, Carla; Veralli, Roberta; Francesconi, Maria; Caccuri, Francesca; De Cesaris, Marina; De Flora, Cecilia; Ceccarelli, Giancarlo; Spoto, Silvia; Caruso, Arnaldo; Pascarella, Stefano; Riva, Elisabetta; Ciccozzi, Massimo.
  • Angeletti S; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Giovanetti M; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
  • Fogolari M; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Cella E; Burnett School of Biomedical Sciences, University of Central Florida, Orlando, Florida, USA.
  • De Florio L; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Lintas C; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Veralli R; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Francesconi M; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Caccuri F; Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
  • De Cesaris M; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • De Flora C; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy.
  • Ceccarelli G; Department of Public Health and Infectious Diseases, Policlinico Umberto I Università 'Sapienza', Rome, Italy.
  • Spoto S; Diagnostic and Therapeutic Medicine Division, University Campus Bio-Medico of Rome, Rome, Italy.
  • Caruso A; Department of Molecular and Translational Medicine, Section of Microbiology, University of Brescia, Brescia, Italy.
  • Pascarella S; Department of Biochemical Sciences "A. Rossi Fanelli", University of Rome "La Sapienza", Rome, Italy.
  • Riva E; Unit of Virology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Ciccozzi M; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy.
J Med Virol ; 94(4): 1689-1692, 2022 04.
Article in English | MEDLINE | ID: covidwho-1718387
ABSTRACT
The appearance of emerging variants of SARS-CoV-2 carrying mutations into the spike protein has recently raised concern with respect to tracking their transmission and mitigating the impact in the evolving pandemic across countries. AY.4.2, a recently detected Delta variant sublineage, is considered a new variant under investigation (VUI) as it carries specific genetic signatures present in the spike protein, called Y145H and A222V. Here, using genomic epidemiology, we provide the first preliminary insight regarding the circulation of this emerging VUI in Italy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27451

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Genome, Viral / SARS-CoV-2 / COVID-19 Type of study: Observational study / Randomized controlled trials Topics: Variants Limits: Adolescent / Adult / Aged / Child / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27451