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What is the true place of the SARS-CoV-2 rapid point-of-care antigen test in the hospital setting? Lessons learned from real life.
Roger, Steven; Lefeuvre, Caroline; Pivert, Adeline; Ducancelle, Alexandra; Savary, Dominique; Bouthry, Élise; Le Guillou-Guillemette, Hélène.
  • Roger S; Département de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.
  • Lefeuvre C; Département de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.
  • Pivert A; Department of Virology, HIFIH, SFR ICAT, University of Angers, Angers, France.
  • Ducancelle A; Département de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.
  • Savary D; Department of Virology, HIFIH, SFR ICAT, University of Angers, Angers, France.
  • Bouthry É; Département de Biologie des Agents Infectieux, Laboratoire de Virologie, CHU Angers, Angers, France.
  • Le Guillou-Guillemette H; Department of Virology, HIFIH, SFR ICAT, University of Angers, Angers, France.
J Med Virol ; 94(4): 1723-1727, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1718404
ABSTRACT
To assist in the clinical management of patients and to support infection control, we tested the use of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) point-of-care antigen test (AgPOC) for unplanned hospitalization, coupled with a nucleic acid amplification test (NAAT) using specimens collected at the same time upon arrival. The aim of this study was to assess the performance of the AgPOC in this specific use compared to NAAT for SARS-CoV-2 diagnosis, in the context of the low prevalence of infection. For 5 months (between two peaks in France of the SARS-CoV-2 pandemic), all patients admitted who undertook the AgPOC/NAAT paired tests were included in the study. AgPOC performances were determined considering the clinical status and the delay of symptoms onset. NAAT and AgPOC results were available for 4425 subjects. AgPOC results showed a homogeneous specificity (>97%) but a low sensitivity at 45.8%. Considering the national guidelines, sensitivity dropped to 32.5% in cases of symptomatic patients with symptoms older than 5 days or more. This study shows the poor performance of AgPOC for entry screening of patients in hospitals. AgPOC may represent a useful tool in the hospital setting only if the use is restricted to patients with consistent symptoms less than 4 days old.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Point-of-Care Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 / Hospitals Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27505

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Point-of-Care Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 / Hospitals Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2022 Document Type: Article Affiliation country: Jmv.27505