Current status of potential therapeutic candidates for the COVID-19 crisis.
Brain Behav Immun
; 87: 59-73, 2020 07.
Article
in English
| MEDLINE | ID: covidwho-1719339
ABSTRACT
As of April 15, 2020, the ongoing coronavirus disease 2019 (COVID-2019) pandemic has swept through 213 countries and infected more than 1,870,000 individuals, posing an unprecedented threat to international health and the economy. There is currently no specific treatment available for patients with COVID-19 infection. The lessons learned from past management of respiratory viral infections have provided insights into treating COVID-19. Numerous potential therapies, including supportive intervention, immunomodulatory agents, antiviral therapy, and convalescent plasma transfusion, have been tentatively applied in clinical settings. A number of these therapies have provided substantially curative benefits in treating patients with COVID-19 infection. Furthermore, intensive research and clinical trials are underway to assess the efficacy of existing drugs and identify potential therapeutic targets to develop new drugs for treating COVID-19. Herein, we summarize the current potential therapeutic approaches for diseases related to COVID-19 infection and introduce their mechanisms of action, safety, and effectiveness.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
Type of study:
Prognostic study
Topics:
Traditional medicine
/
Vaccines
Language:
English
Journal:
Brain Behav Immun
Journal subject:
Allergy and Immunology
/
Brain
/
Psychophysiology
Year:
2020
Document Type:
Article
Affiliation country:
J.bbi.2020.04.046
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