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Renin-angiotensin system: Basic and clinical aspects-A general perspective.
Vargas Vargas, Rafael Antonio; Varela Millán, Jesús María; Fajardo Bonilla, Esperanza.
  • Vargas Vargas RA; Universidad Militar Nueva Granada, Facultad de medicina, Bogotá, Colombia; Universidad Santo Tomás, Maestría en actividad física para la salud, Bogotá, Colombia. Electronic address: rvargas3200@hotmail.com.
  • Varela Millán JM; Universidad Militar Nueva Granada, Facultad de medicina, Bogotá, Colombia; Universidad Santo Tomás, Maestría en actividad física para la salud, Bogotá, Colombia.
  • Fajardo Bonilla E; Universidad Militar Nueva Granada, Facultad de medicina, Bogotá, Colombia.
Endocrinol Diabetes Nutr (Engl Ed) ; 69(1): 52-62, 2022 Jan.
Article in English | MEDLINE | ID: covidwho-1719686
ABSTRACT
The renin-angiotensin system (RAS) is one of the most complex hormonal regulatory systems, involving several organs that interact to regulate multiple body functions. The study of this system initially focused on investigating its role in the regulation of both cardiovascular function and related pathologies. From this approach, pharmacological strategies were developed for the treatment of cardiovascular diseases. However, new findings in recent decades have suggested that the RAS is much more complex and comprises two subsystems, the classic RAS and an alternative RAS, with antagonistic effects that are usually in equilibrium. The classic system is involved in pathologies where inflammatory, hypertrophic and fibrotic phenomena are common and is related to the development of chronic diseases that affect various body systems. This understanding has been reinforced by the evidence that local renin-angiotensin systems exist in many tissue types and by the role of the RAS in the spread and severity of COVID-19 infection, where it was discovered that viral entry into cells of the respiratory system is accomplished through binding to angiotensin-converting enzyme 2, which is present in the alveolar epithelium and is overexpressed in patients with chronic cardiometabolic diseases. In this narrative review, preclinical and clinical aspects of the RAS are presented and topics for future research are discussed some aspects are raised that should be clarified in the future and that call for further investigation of this system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Endocrinol Diabetes Nutr (Engl Ed) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / COVID-19 Type of study: Prognostic study / Reviews Limits: Humans Language: English Journal: Endocrinol Diabetes Nutr (Engl Ed) Year: 2022 Document Type: Article