Risk factors of severe COVID-19 in people with multiple sclerosis : A systematic review and meta-analysis.
Rev Neurol (Paris)
; 178(1-2): 121-128, 2022.
Article
in English
| MEDLINE | ID: covidwho-1720667
ABSTRACT
OBJECTIVES:
To gather, synthesize, and meta-analyze data regarding the risk factors associated with a severe course of COVID-19 among patients with multiple sclerosis (pwMS).METHODS:
MEDLINE, Embase, Scopus, and WoS were searched in May 2021. Briefly, the eligibility criteria included 1) studies assessing COVID-19 severity among adult pwMS; 2) definitive diagnoses or high clinical suspicion of COVID-19; 3) a categorization of COVID-19 severity into at least two categories; 4) quantitative effect size and precision measurements; and 5) English language; and 6) clear effect size/precision measures. internal validity of studies was assessed using the NIH Quality Assessment Tools. A list of possible risk factors was created based on the search results and was later used in extraction, synthesis, and meta-analysis of the data.RESULTS:
Thirteen studies were included in the syntheses. Outcome measures were either extracted from the papers, obtained from the primary researchers or calculated manually. The meta-analyses showed a significantly (P<0.05) increased odds of a severe COVID-19 in pwMS with all of the assessed risk factors, except smoking and most DMTs.CONCLUSION:
This study facilitates evidence-based risk/benefit assessments in practice. Older men with progressive MS on anti-CD20 therapies are more at risk of an unfortunate COVID-19 outcome.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Multiple Sclerosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Long Covid
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
English
Journal:
Rev Neurol (Paris)
Year:
2022
Document Type:
Article
Affiliation country:
J.neurol.2021.10.003
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