Antiviral properties of Cistus .. incanus L. Pandalis proven in SARS-CoV-2 in vitro
Zeitschrift f..r Phytotherapie
; 42(3):121-126, 2021.
Article
in German
| CAB Abstracts | ID: covidwho-1721673
ABSTRACT
Due to lack of reliable therapy and insufficient available vaccines against SARS-CoV-2, researchers are looking for promising and effective therapy in substances that are already available. The objective of the current study is to investigate whether the herbal preparation Cystus Pandalis.. (CPE) has in vitro antiviral properties against SARS-CoV-2. CPE has already proved to be effective against several other viruses. At the Fraunhofer Institute for Cell Therapy and Immunology (IZI), cell cultures treated with Cystus Pandalis.. extract were infected with SARS-CoV-2, and the reduction in the infection rate was evaluated by comparing focus-forming units. An almost complete reduction in the CPE infection rate was observed at concentrations of greater than 15.6 ..g/ml with a calculated EC50 (mean effective concentration) of 1.94 ..g/ml. The mechanism of action of this extract may be based on the highly polymeric polyphenols that envelop certain viral epitopes, whereby CPE acts as an entry inhibitor. The high in vitro activity of CPE seems to make it a reasonable candidate for prophylaxis against SARS-CoV-2.
Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; Pesticides and Drugs; Control [HH405]; Non-food/Non-feed Plant Products [SS200]; Animal and in vitro Models for Pharmaceuticals [VV450]; in vitro; antiviral properties; human diseases; medicinal plants; mode of action; polyphenols; viral diseases; coronavirus disease 2019; traditional medicines; herbal drugs; plant extracts; Severe acute respiratory syndrome coronavirus 2; man; Cistus; plants; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Cistaceae; Malvales; eudicots; angiosperms; Spermatophyta; SARS-CoV-2; anti-viral properties; drug plants; medicinal herbs; officinal plants; viral infections; herbal medicines
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Language:
German
Journal:
Zeitschrift f..r Phytotherapie
Year:
2021
Document Type:
Article
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