Hypothesis: SARS-CoV-2 transmission is predominated by the short-range airborne route and exacerbated by poor ventilation
Indoor Air
; 31(4):921-925, 2021.
Article
in English
| GIM | ID: covidwho-1723219
ABSTRACT
Ambient fine particulate matter (PM2.5), as one of the predominant air pollutants, has achieved effective control in recent years in China. Whether the use of indoor air purifiers is still necessary needs further exploration. A randomized crossover trial was conducted in 54 healthy students in Beijing, China. Participants were randomized assigned to the use of real or sham high-efficiency particulate air filter (HEPA) for a week and changed the status after a washout period. Health measurements of cardiorespiratory biomarkers were performed at the end of each period. Linear mixed-effects models were used to evaluate the association between PM2.5 exposure and cardiorespiratory biomarkers. Compared with sham air purification, average diastolic blood pressure (DBP), fractional exhaled nitric oxide (FeNO), and 8-isoprostane (8-isoPGF2-a) levels decreased significantly in the real purification. The effects of indoor air purification on lung function indicators including forced expiratory volume in one second (FEV1), peak expiratory flow (PEF), and forced expiratory flow between the 25th and 75th percentile of forced vital capacity (FEF25%-75%) were also significant. Our findings showed a protective effect of indoor HEPA air purifiers on cardiorespiratory health of young healthy adults reflected by the decreased blood pressure, respiratory inflammation, and systematic oxidative stress and improved lung function.
10102-43-9; lung function; air pollutants; air pollution; human diseases; particulate matter; adverse effects; biochemical markers; blood pressure; buildings; environmental health; indoor air pollution; inflammation; lungs; nitric oxide; oxidation; oxidative stress; public health; air quality; air filters; man; China; Beijing; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; APEC countries; East Asia; Asia; high Human Development Index countries; upper-middle income countries; Northern China; atmospheric pollution; People's Republic of China; adverse reactions; Peking; biomarkers
Full text:
Available
Collection:
Databases of international organizations
Database:
GIM
Language:
English
Journal:
Indoor Air
Year:
2021
Document Type:
Article
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