Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Science
; 374(6571): 1127-1133, 2021 Nov 26.
Article
in English
| MEDLINE | ID: covidwho-1723460
ABSTRACT
Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type specific. Higher levels of European ancestry are associated with increased type I interferon pathway activity in early infection, which predicts reduced viral titers at later time points. Substantial population-associated variation is explained by cis-expression quantitative trait loci that are differentiated by genetic ancestry. Furthermore, genetic ancestryassociated genes are enriched among genes correlated with COVID-19 disease severity, suggesting that the early immune response contributes to ancestry-associated differences for multiple viral infection outcomes.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Black or African American
/
Leukocytes, Mononuclear
/
White People
/
Influenza, Human
/
Influenza A Virus, H1N1 Subtype
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
/
Young adult
Language:
English
Journal:
Science
Year:
2021
Document Type:
Article
Affiliation country:
Science.abg0928
Similar
MEDLINE
...
LILACS
LIS