Dying cells fan the flames of inflammation.
Science
; 374(6571): 1076-1080, 2021 Nov 26.
Article
in English
| MEDLINE | ID: covidwho-1723462
ABSTRACT
Inflammatory processes that recruit leukocytes to injured or infected tissues are crucial for tissue repair and the elimination of pathogens. However, excessive or chronic inflammation promotes tissue damage and disease, as in arthritis, atherosclerosis, inflammatory bowel disease, and COVID-19. Intracellular constituents released from dying cells are among the stimuli that trigger proinflammatory gene expression programs in innate immune cells. We explore how programmed cell death mechanismsapoptosis, necroptosis, and pyroptosismay contribute to inflammatory disease. We discuss inhibition of cell death as a potential therapeutic strategy, focusing on the targets RIPK1 (receptor interacting serine/threonine kinase 1), NLRP3 (NLR family pyrin domain containing 3), and GSDMD (gasdermin D) as important mediators of lytic cell death. We also consider the potential benefits of limiting membrane rupture rather than cell death by targeting NINJ1.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Apoptosis
/
Pyroptosis
/
Necroptosis
/
Inflammation
Limits:
Animals
/
Humans
Language:
English
Journal:
Science
Year:
2021
Document Type:
Article
Affiliation country:
Science.abi5934
Similar
MEDLINE
...
LILACS
LIS