Thromboembolic clot perviousness in COVID-19: A case-control study
Stroke
; 53(SUPPL 1), 2022.
Article
in English
| EMBASE | ID: covidwho-1724024
ABSTRACT
Background:
Large vessel occlusion (LVO) is the most common stroke subtype for those patient's presenting with COVID-19. Clot perviousness, or a clot's permeability to iodinated contrast, provides insight to an individual's responsiveness of hyperacute revascularization, clot origin and functional post-stroke outcomes. We aimed to calculate LVO perviousness for those with and without COVID-19 and its association with revascularization and outcomes.Methods:
This is a retrospective case-control study for individuals presenting with middle cerebral artery (MCA) LVO with and without COVID-19 positivity. Clot perviousness was calculated by a blinded experienced neuroradiologist. Perviousness scores were compared with demographic and comorbidity information as well as revascularization and functional outcomes.Results:
18 individuals with a MCA LVO (9 COVID-19 infected) were included. Those with COVID-19 were significantly more likely to have diabetes mellitus [67% (6/9) versus 11% (1/9), p = 0.05] and hypertension [89% (8/9) versus 22% (2/9), p = 0.02]. Clot perviousness trended lower in the COVID-19 group [11.0 (8.2 - 26.4) versus 31.7 (30.4 - 39.2), p = 0.10]. Those with COVID-19 infection tended to have a lower clot pervious score, [22% (2/9) versus 78% (7/9), p =0.057]. The majority of those presenting with COVID-19 died during the hospitalization.Conclusions:
Our data suggests for those with COVID-19 and MCA LVO, clots tended to be more impermeable to iodinated contrast. This finding may be due to the underlying coagulopathy of COVID-19, namely alternations in fibrin homeostasis. (Figure Presented).
endogenous compound; fibrin; adult; blood vessel occlusion; case control study; clinical article; comorbidity; conference abstract; controlled study; coronavirus disease 2019; COVID-19-associated coagulopathy; demography; diabetes mellitus; female; homeostasis; hospital mortality; hospitalization; human; hypertension; iodination; male; middle cerebral artery; neuroradiologist; retrospective study; revascularization; thromboembolism
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Observational study
Language:
English
Journal:
Stroke
Year:
2022
Document Type:
Article
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