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Multiple sclerosis incidence in latin america and the caribbean (emelac project)-uruguayan preliminary results
Multiple Sclerosis Journal ; 28(2):NP15, 2022.
Article in English | EMBASE | ID: covidwho-1724268
ABSTRACT

Introduction:

The worldwide incidence of multiple sclerosis (MS) is estimated to be 0.5-10 cases per 100.000 person-years and is probably increasing. Incidence in Uruguay was estimated in 1.2 cases per 100.000 person-years in a 2015 study.

Objectives:

To determine MS incidence in Uruguay

Methods:

Following the EMELAC protocol (MS in Latin America and Caribbean region), we conducted an observational, prospective, population based study to determine MS incidence in Uruguay. The population studied included people living in Uruguay, older than 18 years of age, between 7-1-2019 and 6-30-2021. The diagnosis was based on the 2017 McDonald criteria. Multiple data sources were employed. All possible cases of MS were reviewed by the research team. Cases with diagnostic uncertainty were re-reviewed by an outside coauthor (D.O.).

Results:

137 new MS cases were confirmed after review including 100 females (73%). 65 of them were examined directly by the research team (47%). The sex ratio was 2.71 female/male. Age range was 18 to 62 with a median of 35 and an interquartile range of 16.5 (26.5-43). 129 (94%) cases were relapsing-remitting MS, 7 (5%) primary progressive MS and 1 secondary progressive MS. Global incidence rate was 2.55 cases per 100.000 person-years, 3.55 in females and 1.45 in males. The highest incidence was observed in the 35-39 years old group (5.28 cases per 100.000 person-years).

Conclusions:

According to MS Atlas, Uruguay has a low incidence rate (2.0-3.99). Despite this, the MS incidence in Uruguay is one of the highest in Latin America. Age and gender distribution were similar to other studies. We found a lower proportion of primary progressive MS. COVID19 pandemic raised methodological problems which could have led to an underestimation of the incidence. These preliminary results will be completed in upcoming publications.
Keywords

Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Country/Region as subject: South America / Uruguay Language: English Journal: Multiple Sclerosis Journal Year: 2022 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: EMBASE Type of study: Observational study Country/Region as subject: South America / Uruguay Language: English Journal: Multiple Sclerosis Journal Year: 2022 Document Type: Article