Correlation of SARSCoV2 to cancer: Carcinogenic or anticancer? (Review).
Int J Oncol
; 60(4)2022 04.
Article
in English
| MEDLINE | ID: covidwho-1726131
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARSCoV2) is highly infectious and pathogenic. Among patients with severe SARSCoV2caused by corona virus disease 2019 (COVID19), those complicated with malignant tumor are vulnerable to COVID19 due to compromised immune function caused by tumor depletion, malnutrition and antitumor treatment. Cancer is closely related to the risk of severe illness and mortality in patients with COVID19. SARSCoV2 could promote tumor progression and stimulate metabolism switching in tumor cells to initiate tumor metabolic modes with higher productivity efficiency, such as glycolysis, for facilitating the massive replication of SARSCoV2. However, it has been shown that infection with SARSCoV2 leads to a delay in tumor progression of patients with natural killer cell (NK cell) lymphoma and Hodgkin's lymphoma, while SARSCoV2 elicited antitumor immune response may exert a potential oncolytic role in lymphoma patients. The present review briefly summarized potential carcinogenicity and oncolytic characteristics of SARSCoV2 as well as strategies to protect patients with cancer during the COVID19 pandemic.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
/
Neoplasms
Type of study:
Prognostic study
Topics:
Long Covid
/
Vaccines
Limits:
Humans
Language:
English
Journal subject:
Neoplasms
Year:
2022
Document Type:
Article
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