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Tumefactive Demyelinating Brain Lesion Developing after Administration of Adenovector-Based COVID-19 Vaccine: A Case Report.
Garg, Ravindra K; Malhotra, Hardeep S; Kumar, Neeraj; Pandey, Shweta; Patil, Manish R; Uniyal, Ravi; Rizvi, Imran.
  • Garg RK; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Malhotra HS; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Kumar N; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Pandey S; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Patil MR; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Uniyal R; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
  • Rizvi I; Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.
Neurol India ; 70(1): 409-411, 2022.
Article in English | MEDLINE | ID: covidwho-1726256
ABSTRACT

Background:

Postmarketing surveillance of COVID-19 vaccination reveals that the COVID-19 vaccine administration is associated with several rare but serious neurological complications. Case Report We report a case of new-onset tumefactive demyelinating brain lesion that developed after administration of an adenovector-based COVID-19 vaccine. A middle-aged female presented with recent right hemiparesis, which was noticed 2 days after she received the first dose of the vaccine. Magnetic resonance imaging (MRI) revealed a large subcortical T2/FLAIR hyperintensities involving corpus callosum as well. The patient responded to oral methylprednisolone. At 4 weeks, a follow-up MRI revealed a reduction in size of the lesion.

Conclusion:

To conclude, adenovector-based COVID-19 vaccination may be associated with a tumefactive demyelinating lesion.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Demyelinating Diseases / COVID-19 Vaccines / COVID-19 Type of study: Case report Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Neurol India Year: 2022 Document Type: Article Affiliation country: 0028-3886.338642

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Demyelinating Diseases / COVID-19 Vaccines / COVID-19 Type of study: Case report Topics: Vaccines Limits: Female / Humans / Middle aged Language: English Journal: Neurol India Year: 2022 Document Type: Article Affiliation country: 0028-3886.338642