The causal relationship between circulating cytokines and critically ill COVID-19: A bidirectional Mendelian randomization analysis.
J Glob Health
; 12: 05010, 2022.
Article
in English
| MEDLINE | ID: covidwho-1726723
ABSTRACT
Background:
In this study, we performed a bidirectional mendelian randomization analysis on circulating cytokines and critically ill COVID-19.Methods:
Both the exposure and outcome data were obtained from public genome wide association study (GWAS) database. We extracted independent instrumental variables from exposure at genome level significance (P < 5 × 10-8). Wald ratio or inverse variance weighted (IVW) method were used for estimating the causal relationships between circulating cytokines and critically ill COVID-19.Results:
Only IL5 (cytokines to critically ill COVID-19 direction) and bNGF, IL8 (critically ill COVID-19 to cytokines direction) showed suggestive causal relations. However, these associations lost significance after FDR correction. Another validation data set of critically ill COVID-19 did not confirm these associations, either.Conclusions:
Our Mendelian randomization did not find causal relationships between analyzable circulating cytokines and critically ill COVID-19.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Mendelian Randomization Analysis
/
COVID-19
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Glob Health
Year:
2022
Document Type:
Article
Affiliation country:
Jogh.12.05010
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