A Novel Association Between Coronavirus Disease 2019 and Normocomplementemic Rapidly Progressive Glomerulonephritis-Crescentic Immunoglobulin A Nephropathy: A Report of Two Pediatric Cases.

ABSTRACT

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been predominately associated with respiratory illness. Acute kidney injury (AKI) is the most common reported kidney involvement. Kidney complications, including proteinuria, hematuria, and rarely collapsing glomerulopathy (CG), a form of focal segmental glomerulosclerosis (FSGS), are also well known now and are frequently documented in the literature published so far. We present two cases of glomerulonephritis (GN) in the setting of AKI in COVID-19 infection in children. Kidney biopsy specimens showed immunoglobulin A nephropathy (IgAN) with crescentic GN (CGN) with acute tubular injury with focal medium artery vasculitis. The patients exhibited a severe presentation and rapid progression to end-stage renal disease (ESRD). This report attempts to add a bit to the evolving information on COVID-19 disease, especially in children as far as kidney involvement is concerned.