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Depletion and Dysfunction of Dendritic Cells: Understanding SARS-CoV-2 Infection.
Chang, Teding; Yang, Jingzhi; Deng, Hai; Chen, Deng; Yang, XiangPing; Tang, Zhao-Hui.
  • Chang T; Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China.
  • Yang J; Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China.
  • Deng H; Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China.
  • Chen D; Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China.
  • Yang X; Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tang ZH; Division of Trauma & Surgical Critical Care, Department of Surgery, Tongji Hospital, Tongji, China.
Front Immunol ; 13: 843342, 2022.
Article in English | MEDLINE | ID: covidwho-1903004
ABSTRACT
Uncontrolled severe acute respiratory syndrome-coronavirus (SARS-CoV)-2 infection is closely related to disorders of the innate immune and delayed adaptive immune systems. Dendritic cells (DCs) "bridge" innate immunity and adaptive immunity. DCs have important roles in defending against SARS-CoV-2 infection. In this review, we summarize the latest research concerning the role of DCs in SARS-CoV-2 infection. We focus on the complex interplay between DCs and SARS-CoV-2 pyroptosis-induced activation; activation of the renin-angiotensin-aldosterone system; and activation of dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin. We also discuss the decline in DC number, the impaired antigen-presentation capability, and the reduced production of type-I interferon of DCs in severe SARS-CoV-2 infection. In addition, we discuss the potential mechanisms for pathological activation of DCs to understand the pattern of SARS-CoV-2 infection. Lastly, we provide a brief overview of novel vaccination and immunotherapy strategies based on DC targeting to overcome SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.843342

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / SARS-CoV-2 / COVID-19 Topics: Vaccines Limits: Animals / Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.843342