Role of etophylline and theophylline prolonged release tablet in COVID-19 associated sinus node dysfunction
Journal of the Association of Physicians of India
; 70(January):38-39, 2022.
Article
in English
| GIM | ID: covidwho-1823710
ABSTRACT
During COVID-19 pandemic, one of the most common arrythmia reported with this illness is sinus bradycardia. Treatment for COVID-19 and associated cardiac dysfunction is still evolving. Temporary pacemaker insertion is difficult due to pandemic and risk of spread of infection to the additional staff involved. Orciprenaline stimulates the sino-atrial and atrioventricular nodes and accelerates atrioventricular conduction. Theophylline improves sinus node function in subjects with sinus bradycardia and enhances atrioventricular nodal conduction We report a case series of 10 patients admitted in dedicated COVID-19 ICUs and developed sinus node dysfunction. All of these patients were started on etophylline and theophylline prolonged release tablet (150 mg) once a day. On subsequent follow up after 72 hours, all patients reported heart rate well within normal range. COVID-19 virus directly involves the myocardium by entering the cardiac myocytes resulting in inflammation and injury. As the sinus bradycardia due to COVID-19 is usually transient and respond well this drug, short course of this drug could be added to treat this arrythmia in future.
58-55-9; bradycardia; case reports; clinical aspects; complications; coronavirus disease 2019; drug therapy; follow up; heart; heart rate; human diseases; inflammation; myocardium; pandemics; sinus arrhythmia; theophylline; viral diseases; man; Severe acute respiratory syndrome coronavirus 2; India; Rajasthan; Commonwealth of Nations; lower-middle income countries; medium Human Development Index countries; South Asia; Asia; Homo; Hominidae; primates; mammals; vertebrates; Chordata; animals; eukaryotes; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; clinical picture; chemotherapy; cardiac muscle; heart muscle; SARS-CoV-2; viral infections
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Collection:
Databases of international organizations
Database:
GIM
Language:
English
Journal:
Journal of the Association of Physicians of India
Year:
2022
Document Type:
Article
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