Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting

Hauser, Blake M.; Sangesland, Maya, St. Denis, Kerri J.; Lam, Evan C.; Case, James Brett, Windsor, Ian W.; Feldman, Jared, Caradonna, Timothy M.; Kannegieter, Ty, Diamond, Michael S.; Balazs, Alejandro B.; Lingwood, Daniel, Schmidt, Aaron G.

Hauser, Blake M.; Sangesland, Maya, St. Denis, Kerri J.; Lam, Evan C.; Case, James Brett, Windsor, Ian W.; Feldman, Jared, Caradonna, Timothy M.; Kannegieter, Ty, Diamond, Michael S.; Balazs, Alejandro B.; Lingwood, Daniel, Schmidt, Aaron G..

Cell reports ; 2022.

Article in English | EuropePMC | ID: covidwho-1728215

ABSTRACT

ABSTRACT

Hauser et al. use structure-guided design to engineer SARS-2 immunogens that direct immune responses to conserved viral sites in context of preexisting immunity. In mice, these immunogens elicit antibodies that potently neutralize related coronaviruses, including those of potential pandemic concern. Structural characterization of selected antibodies explains this observation.

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Collection: Databases of international organizations Database: EuropePMC Language: English Journal: Cell reports Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: EuropePMC Language: English Journal: Cell reports Year: 2022 Document Type: Article