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Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids.
Smirnova, Irina; Petrova, Anastasiya; Lobov, Alexander; Minnibaeva, El'za; Phoung, Thao Tran Thi; Van, Loc Tran; Khine, Myint Myint; Esaulkova, Iana; Slita, Alexander; Zarubaev, Vladimir; Kazakova, Oxana.
  • Smirnova I; Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 pr. Oktyabrya, 450054, Ufa, Russian Federation. si8081@yandex.ru.
  • Petrova A; Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 pr. Oktyabrya, 450054, Ufa, Russian Federation.
  • Lobov A; Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 pr. Oktyabrya, 450054, Ufa, Russian Federation.
  • Minnibaeva E; Department of Technical Chemistry and Materials Science, Bashkir State University, Faculty of Engineering, 32 Zaki Validi, 450076, Ufa, Russian Federation.
  • Phoung TTT; Institute of Chemistry - Vietnamese Academy of Science and Technology 18, Hoang Quoc Viet street 18 Cau Giay district, Hanoi, Vietnam.
  • Van LT; Institute of Chemistry - Vietnamese Academy of Science and Technology 18, Hoang Quoc Viet street 18 Cau Giay district, Hanoi, Vietnam.
  • Khine MM; Department of Chemistry, University of Yangon, University Avenue Road, Kamayut Township, 11041, Yangon, Myanmar.
  • Esaulkova I; Department of virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental virology laboratory, 14 Mira St., St. Petersburg, 197001, Russian Federation.
  • Slita A; Department of virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental virology laboratory, 14 Mira St., St. Petersburg, 197001, Russian Federation.
  • Zarubaev V; Department of virology, St. Petersburg Pasteur Institute of Epidemiology and Microbiology, Experimental virology laboratory, 14 Mira St., St. Petersburg, 197001, Russian Federation.
  • Kazakova O; Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 71 pr. Oktyabrya, 450054, Ufa, Russian Federation.
J Antibiot (Tokyo) ; 75(5): 258-267, 2022 05.
Article in English | MEDLINE | ID: covidwho-1728737
ABSTRACT
A series of lupane-, oleanane- and dammarane-based triterpenoids with 3ß-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3ß-amino-28-oxoallobetulin 11 showed antiviral activity with IC50 1.1 and 2.6 µg ml-1, and selectivity index of 19 and 10, respectively.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Triterpenes / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Experimental Studies Limits: Humans Language: English Journal: J Antibiot (Tokyo) Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Triterpenes / Influenza, Human / Influenza A Virus, H1N1 Subtype Type of study: Experimental Studies Limits: Humans Language: English Journal: J Antibiot (Tokyo) Year: 2022 Document Type: Article