Pleiotropic effects of vitamin D including aspects of COVID-19
Journal Fur Mineralstoffwechsel & Muskuloskelettale Erkrankungen
; 28(1):2-11, 2021.
Article
in German
| Web of Science | ID: covidwho-1729450
ABSTRACT
Vitamin D is provided by nutritional sources or by skin synthesis under the influence of UV light. In the liver, vitamin D is converted to 25(OH)-vitamin D and finally in the kidney to 1,25(OH)2-vitamin D, which is a hormone regulating bone andmineralmetabolism. Besides the kidneys, other organs are also capable of making 1,25(OH)2-vitamin D, which exerts autocrine and paracrine effects. For these pleiotropic effects, a continuous vitamin D supply (daily supplements) with moderate doses is more effective than high-dose bolus applications. Beside the classical effects of 1,25(OH)2-vitamin D on the musculoskeletal system, there is good evidence for extraskeletal effects on the immune system. A good vitamin D supply can reduce the risk of respiratory infections. At the present time, the preventive and therapeutic use of vitamin D regarding COVID-19 (coronavirus disease 19) is of great interest.
Musculoskeletal system; Autoimmune disease; Respiratory infects; Vitamin; D-supplementation; Diabetesmellitus; beta-cell function; serum 25-hydroxyvitamin d; type-1 diabetes-mellitus; placebo-controlled trial; d supplementation; calcium supplementation; glycemic control; older women; nod mice; t-cells; Endocrinology & Metabolism
Full text:
Available
Collection:
Databases of international organizations
Database:
Web of Science
Type of study:
Experimental Studies
Language:
German
Journal:
Journal Fur Mineralstoffwechsel & Muskuloskelettale Erkrankungen
Year:
2021
Document Type:
Article
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