Real world SARS-COV-2 vaccine effectiveness in a Miami academic institution.
Am J Emerg Med
; 54: 97-101, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1729485
ABSTRACT
BACKGROUND:
To assess the effectiveness of messenger RNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) in preventing emergency department (ED) presentations for acute respiratory illness. BASIC PROCEDURES We conducted a retrospective study assessing adult presentations (age ≥ 18) to the University of Miami Hospital's ED from January 1st through August 25th, 2021, with a SARS-COV-2 PCR test and acute respiratory infection symptoms. Vaccine effectiveness was calculated using a test-negative design. Both univariable and multivariable (adjusted for age, gender, race, insurance status, imputed body mass index [BMI], vaccine type, week of presentation) regression analyses were conducted for the full cohort and subgroups. MAINFINDINGS:
The cohort consisted of 13,203 ED presentations-3134 (23.7%) fully vaccinated and SARS-COV-2 negative, 108 (0.8%) fully vaccinated and SARS-COV-2 positive, 8817 (66.8%) unvaccinated and SARS-COV-2 negative, and 1144 (8.7%) unvaccinated and SARS-COV-2 positive. Unadjusted vaccination effectiveness was 73.4% (95% confidence interval 67.5%,78.3%) and, after adjustment, 73.8% (66.2%,79.7%). The Moderna vaccine's effectiveness was numerically higher (unadjusted 78.2% [68.8%, 84.7%]; adjusted 78.0% [68.1%, 84.9%]) than the Pfizer vaccine's (unadjusted 70.8% [62.9%, 76.9%]; adjusted 73.9% [66.3%,79.8%]). We found a significant difference in adjusted vaccine effectiveness across categories was BMI (p < 0.001)-BMI <25 66.3% (45.3%,79.2%); BMI 25-29 71.3% (56.1%, 81.2%); BMI 30-34 84.5% (71.7%, 91.5%); and BMI ≥35 72.7% (50.5%, 84.9%). PRINCIPALCONCLUSIONS:
We demonstrated excellent real-world effectiveness of mRNA vaccines in preventing ED presentation for SARS-COV-2 in a diverse U.S. COHORT Notably, vaccine effectiveness improved with increasing BMI (until class 2 obesity).Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19 Vaccines
/
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Topics:
Vaccines
Limits:
Adult
/
Humans
Language:
English
Journal:
Am J Emerg Med
Year:
2022
Document Type:
Article
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