Your browser doesn't support javascript.
Endothelial dysfunction in acute and long standing COVID-19: A prospective cohort study.
Oikonomou, Evangelos; Souvaliotis, Nektarios; Lampsas, Stamatios; Siasos, Gerasimos; Poulakou, Garyphallia; Theofilis, Panagiotis; Papaioannou, Theodore G; Haidich, Anna-Bettina; Tsaousi, Georgia; Ntousopoulos, Vasileios; Sakka, Vissaria; Charalambous, Georgios; Rapti, Vasiliki; Raftopoulou, Sylvia; Syrigos, Konstantinos; Tsioufis, Costas; Tousoulis, Dimitris; Vavuranakis, Manolis.
  • Oikonomou E; 3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece. Electronic addres
  • Souvaliotis N; 3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.
  • Lampsas S; 3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.
  • Siasos G; 3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
  • Poulakou G; 3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Theofilis P; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
  • Papaioannou TG; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
  • Haidich AB; Department of Hygiene, Social-Preventive Medicine and Medical Statistics, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Tsaousi G; Department of Anesthesiology and ICU, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
  • Ntousopoulos V; 3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Sakka V; 3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Charalambous G; Emergency Department, "Hippokration" General Hospital, Athens, Greece.
  • Rapti V; 3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Raftopoulou S; Intensive Care Unit, Sotiria Chest Disease Hospital, Athens, Greece.
  • Syrigos K; 3rd Department of Medicine, Medical School, Sotiria Chest Disease Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Tsioufis C; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
  • Tousoulis D; 1st Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Hippokration General Hospital, Athens, Greece.
  • Vavuranakis M; 3rd Department of Cardiology, National and Kapodistrian University of Athens, Medical School, Sotiria Chest Disease Hospital, Athens, Greece.
Vascul Pharmacol ; 144: 106975, 2022 06.
Article in English | MEDLINE | ID: covidwho-2184357
ABSTRACT

BACKGROUND:

Coronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.

METHODS:

In this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital discharge. Medical history and laboratory examinations were performed while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD). Comparison with propensity score-matched cohort (control group) was performed at the acute (upon hospital admission) and follow-up (1 and 6 months) stages.

RESULTS:

Seventy-three patients diagnosed with COVID-19 (37% admitted in ICU) were recruited. FMD was significantly (p < 0.001) impaired in the COVID-19 group (1.65 ± 2.31%) compared to the control (6.51 ± 2.91%). ICU-treated subjects presented significantly impaired (p = 0.001) FMD (0.48 ± 1.01%) compared to those treated in the medical ward (2.33 ± 2.57%). During hospitalization, FMD was inversely associated with Interleukin-6 and Troponin I (p < 0.05 for all). Although, a significant improvement in FMD was noted during the follow-up (acute 1.75 ± 2.19% vs. 1 month 4.23 ± 2.02%, vs. 6 months 5.24 ± 1.62%; p = 0.001), FMD remained impaired compared to control (6.48 ± 3.08%) at 1 month (p < 0.001) and 6 months (p = 0.01) post-hospital discharge.

CONCLUSION:

COVID-19 patients develop a notable endothelial dysfunction, which is progressively improved over a 6-month follow-up but remains impaired compared to healthy controls subjects. Whether chronic dysregulation of endothelial function following COVID-19 could be accompanied by a residual risk for cardiovascular and thrombotic events merits further research.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Vascul Pharmacol Journal subject: Vascular Diseases / Pharmacology Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Vascul Pharmacol Journal subject: Vascular Diseases / Pharmacology Year: 2022 Document Type: Article