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Antibody escape and global spread of SARS-CoV-2 lineage A.27.
Kaleta, Tamara; Kern, Lisa; Hong, Samuel Leandro; Hölzer, Martin; Kochs, Georg; Beer, Julius; Schnepf, Daniel; Schwemmle, Martin; Bollen, Nena; Kolb, Philipp; Huber, Magdalena; Ulferts, Svenja; Weigang, Sebastian; Dudas, Gytis; Wittig, Alice; Jaki, Lena; Padane, Abdou; Lagare, Adamou; Salou, Mounerou; Ozer, Egon Anderson; Nnaemeka, Ndodo; Odoom, John Kofi; Rutayisire, Robert; Benkahla, Alia; Akoua-Koffi, Chantal; Ouedraogo, Abdoul-Salam; Simon-Lorière, Etienne; Enouf, Vincent; Kröger, Stefan; Calvignac-Spencer, Sébastien; Baele, Guy; Panning, Marcus; Fuchs, Jonas.
  • Kaleta T; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Kern L; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Hong SL; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
  • Hölzer M; Methodology and Research Infrastructure, Bioinformatics, Robert Koch Institute, Berlin, Germany.
  • Kochs G; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Beer J; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Schnepf D; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Schwemmle M; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Bollen N; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
  • Kolb P; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Huber M; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Ulferts S; Institute of Experimental and Clinical Pharmacology and Toxicology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Weigang S; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Dudas G; Gothenburg Global Biodiversity Centre, Carl Skottsbergs gata 22B, 413 19, Gothenburg, Sweden.
  • Wittig A; Methodology and Research Infrastructure, Bioinformatics, Robert Koch Institute, Berlin, Germany.
  • Jaki L; Hasso Plattner Institute, Digital Engineering Faculty, University of Potsdam, 14482, Potsdam, Germany.
  • Padane A; Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
  • Lagare A; Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formation (IRESSEF), Rufisque, Senegal.
  • Salou M; Centre de Recherche Médicale et Sanitaire (CERMES), 634 Bld de la Nation, BP:10887, YN034, Niamey, Niger.
  • Ozer EA; Laboratoire de Biologie Moléculaire et d'Immunologie, Département des Sciences Fondamentales, Université de Lomé, Lomé, Togo.
  • Nnaemeka N; Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
  • Odoom JK; National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria.
  • Rutayisire R; Department of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Accra, Ghana.
  • Benkahla A; Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health, Kigali, Rwanda.
  • Akoua-Koffi C; National Reference Laboratory, Rwanda Biomedical Center, Kigali, Rwanda.
  • Ouedraogo AS; Laboratory of BioInformatics bioMathematics, and bioStatistics (BIMS), Institut Pasteur de Tunis, University of Tunis El Manar, Tunis, Tunisia.
  • Simon-Lorière E; Laboratoire Central, Centre Hospitalier et Universitaire de Bouaké, Bouaké, Côte d'Ivoire.
  • Enouf V; Department of Bacteriology and Virology, Souro Sanou University Hospital, Bobo-Dioulasso, Burkina Faso.
  • Kröger S; G5 Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur, Paris, France.
  • Calvignac-Spencer S; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.
  • Baele G; Department of Infectious Disease Epidemiology, Robert Koch Institute, 13353, Berlin, Germany.
  • Panning M; Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute, 13353, Berlin, Germany.
  • Fuchs J; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Nat Commun ; 13(1): 1152, 2022 03 03.
Article in English | MEDLINE | ID: covidwho-1730284
ABSTRACT
In spring 2021, an increasing number of infections was observed caused by the hitherto rarely described SARS-CoV-2 variant A.27 in south-west Germany. From December 2020 to June 2021 this lineage has been detected in 31 countries. Phylogeographic analyses of A.27 sequences obtained from national and international databases reveal a global spread of this lineage through multiple introductions from its inferred origin in Western Africa. Variant A.27 is characterized by a mutational pattern in the spike gene that includes the L18F, L452R and N501Y spike amino acid substitutions found in various variants of concern but lacks the globally dominant D614G. Neutralization assays demonstrate an escape of A.27 from convalescent and vaccine-elicited antibody-mediated immunity. Moreover, the therapeutic monoclonal antibody Bamlanivimab and partially the REGN-COV2 cocktail fail to block infection by A.27. Our data emphasize the need for continued global monitoring of novel lineages because of the independent evolution of new escape mutations.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa / Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-28766-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / SARS-CoV-2 / COVID-19 Type of study: Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: Africa / Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2022 Document Type: Article Affiliation country: S41467-022-28766-y