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Making a case for using γδ T cells against SARS-CoV-2.
Yazdanifar, Mahboubeh; Mashkour, Narges; Bertaina, Alice.
  • Yazdanifar M; Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
  • Mashkour N; Australian Institute of Tropical Health and Medicine, CPHMVS, James Cook University, Townsville, QLD, Australia.
  • Bertaina A; Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Crit Rev Microbiol ; 46(6): 689-702, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-1730391
ABSTRACT
Intensive worldwide efforts are underway to determine both the pathogenesis of SARS-CoV-2 infection and the immune responses in COVID-19 patients in order to develop effective therapeutics and vaccines. One type of cell that may contribute to these immune responses is the γδ T lymphocyte, which plays a key role in immunosurveillance of the mucosal and epithelial barriers by rapidly responding to pathogens. Although found in low numbers in blood, γδ T cells consist the majority of tissue-resident T cells and participate in the front line of the host immune defense. Previous studies have demonstrated the critical protective role of γδ T cells in immune responses to other respiratory viruses, including SARS-CoV-1. However, no studies have profoundly investigated these cells in COVID-19 patients to date. γδ T cells can be safely expanded in vivo using existing inexpensive FDA-approved drugs such as bisphosphonate, in order to test its protective immune response to SARS-CoV-2. To support this line of research, we review insights gained from previous coronavirus research, along with recent findings, discussing the potential role of γδ T cells in controlling SARS-CoV-2. We conclude by proposing several strategies to enhance γδ T cell's antiviral function, which may be used in developing therapies for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus Topics: Vaccines Limits: Animals / Humans Language: English Journal: Crit Rev Microbiol Journal subject: Microbiology Year: 2020 Document Type: Article Affiliation country: 1040841X.2020.1822279

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus Topics: Vaccines Limits: Animals / Humans Language: English Journal: Crit Rev Microbiol Journal subject: Microbiology Year: 2020 Document Type: Article Affiliation country: 1040841X.2020.1822279