The detrimental impact of elevated Ferritin to Iron ratio on in-hospital prognosis of patients with COVID-19.
Expert Rev Mol Diagn
; 22(4): 469-478, 2022 04.
Article
in English
| MEDLINE | ID: covidwho-1730488
ABSTRACT
BACKGROUND:
Acute viral infections, including coronavirus disease 2019 (COVID-19), are characterized by the dysregulation of iron metabolism, resulting in high serum ferritin and low iron levels. RESEARCH DESIGN ANDMETHODS:
This study aimed to evaluate the prospective impact of iron metabolism dysregulation, as expressed by serum Ferritin-to-Iron Ratio (FIR), on the in-hospital prognosis of patients with COVID-19. Serum levels of ferritin and iron, as well as other iron metabolism markers and recognized prognostic indicators of COVID-19 severity, were measured in 362 patients consecutively hospitalized for COVID-19. The prospective relationship between FIR and the risk of the composite outcome of intensive care unit (ICU) admission/in-hospital death was analyzed.RESULTS:
In the population examined (mean age 74 ± 15 years, males 55%), the rates of radiographic signs of pneumonia, respiratory distress, and the need for noninvasive ventilation were higher in patients with high FIR (≥29.2, the 75th percentile) than in those with low FIR (<29.2, the 75th percentile) (p < 0.05 for all comparisons). High FIR was associated with a 1.7-fold (HR 1.709, 95% CI 1.017-2.871, p = 0.043) higher risk of ICU admission/in-hospital death.CONCLUSIONS:
Increasing FIR values significantly and independently predicts worse in-hospital prognosis in hospitalized patients with COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
Type of study:
Cohort study
/
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Expert Rev Mol Diagn
Journal subject:
Molecular Biology
Year:
2022
Document Type:
Article
Affiliation country:
14737159.2022.2052047
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