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Waning effectiveness of SARS-CoV-2 mRNA vaccines in older adults: a rapid review.
Nanishi, Etsuro; Levy, Ofer; Ozonoff, Al.
  • Nanishi E; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
  • Levy O; Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
  • Ozonoff A; Precision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, MA, USA.
Hum Vaccin Immunother ; 18(5): 2045857, 2022 11 30.
Article in English | MEDLINE | ID: covidwho-1730555
ABSTRACT
The U.S. Centers for Disease Control and Prevention (CDC) and other health agencies have recently recommended a booster dose of COVID-19 vaccines for specific vulnerable groups including adults 65 years and older. There is limited evidence whether vaccine effectiveness (VE) in older adults decreases over time, especially against severe COVID-19. We performed a rapid review of published studies available through 4 November 2021 that provide effectiveness data on messenger RNA (mRNA) vaccines approved/licensed in the United States and identified eight eligible studies which evaluated VE in older adults. There is evidence of a decline in VE against both severe acute respiratory syndrome coronavirus 2 infection and severe COVID-19 in older adults among studies which analyzed data up to July-October 2021. Our findings suggest that VE diminishes in older adults, which supports the current recommendation for a booster dose in this population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials / Reviews Topics: Vaccines Limits: Aged / Humans Country/Region as subject: North America Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2022.2045857

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Randomized controlled trials / Reviews Topics: Vaccines Limits: Aged / Humans Country/Region as subject: North America Language: English Journal: Hum Vaccin Immunother Year: 2022 Document Type: Article Affiliation country: 21645515.2022.2045857