Spontaneous tumor regression following COVID-19 vaccination.
J Immunother Cancer
; 10(3)2022 03.
Article
in English
| MEDLINE | ID: covidwho-1731296
ABSTRACT
Vaccination against COVID-19 is critical for immuno-compromised individuals, including patients with cancer. Systemic reactogenicity, a manifestation of the innate immune response to vaccines, occurs in up to 69% of patients following vaccination with RNA-based COVID-19 vaccines. Tumor regression can occur following an intense immune-inflammatory response and novel strategies to treat cancer rely on manipulating the host immune system. Here, we report spontaneous regression of metastatic salivary gland myoepithelial carcinoma in a patient who experienced grade 3 systemic reactogenicity, following vaccination with the mRNA-1273 COVID-19 vaccine. Histological and immunophenotypic inspection of the postvaccination lung biopsy specimens showed a massive inflammatory infiltrate with scant embedded tumor clusters (<5%). Highly multiplexed imaging mass cytometry showed that the postvaccination lung metastasis samples had remarkable immune cell infiltration, including CD4+ T cells, CD8+ T cells, natural killer cells, B cells, and dendritic cells, which contrasted with very low levels of these cells in the prevaccination primary tumor and lung metastasis samples. CT scans obtained 3, 6, and 9 months after the second vaccine dose demonstrated persistent tumor shrinkage (50%, 67%, and 73% reduction, respectively), suggesting that vaccination stimulated anticancer immunity. Insight This case suggests that the mRNA-1273 COVID-19 vaccine stimulated anticancer immunity and tumor regression.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parotid Neoplasms
/
Myoepithelioma
/
Immunogenicity, Vaccine
/
2019-nCoV Vaccine mRNA-1273
/
Immunity, Innate
/
Lung Neoplasms
Type of study:
Case report
Topics:
Vaccines
Limits:
Female
/
Humans
/
Middle aged
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
Jitc-2021-004371
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