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Disrupted Peyer's Patch Microanatomy in COVID-19 Including Germinal Centre Atrophy Independent of Local Virus.
Trevelin, Silvia C; Pickering, Suzanne; Todd, Katrina; Bishop, Cynthia; Pitcher, Michael; Garrido Mesa, Jose; Montorsi, Lucia; Spada, Filomena; Petrov, Nedyalko; Green, Anna; Shankar-Hari, Manu; Neil, Stuart J D; Spencer, Jo.
  • Trevelin SC; Peter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Pickering S; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Todd K; National Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Bishop C; National Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Pitcher M; Peter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Garrido Mesa J; National Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Montorsi L; Peter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Spada F; National Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Petrov N; National Institute for Health Research (NIHR) Guy's and St. Thomas Biomedical Research Centre at Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Green A; Department of Histopathology, Guy's and St. Thomas NHS Foundation Trust and King's College London, London, United Kingdom.
  • Shankar-Hari M; Centre for Inflammation Research, Queen's Medical Research Institute, The University of Edinburgh, Edinburgh, United Kingdom.
  • Neil SJD; Department of Infectious Diseases, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
  • Spencer J; Peter Gorer Department of Immunology, School of Immunology and Microbial Sciences, King's College London, London, United Kingdom.
Front Immunol ; 13: 838328, 2022.
Article in English | MEDLINE | ID: covidwho-1731785
ABSTRACT
Confirmed SARS-coronavirus-2 infection with gastrointestinal symptoms and changes in microbiota associated with coronavirus disease 2019 (COVID-19) severity have been previously reported, but the disease impact on the architecture and cellularity of ileal Peyer's patches (PP) remains unknown. Here we analysed post-mortem tissues from throughout the gastrointestinal (GI) tract of patients who died with COVID-19. When virus was detected by PCR in the GI tract, immunohistochemistry identified virus in epithelium and lamina propria macrophages, but not in lymphoid tissues. Immunohistochemistry and imaging mass cytometry (IMC) analysis of ileal PP revealed depletion of germinal centres (GC), disruption of B cell/T cell zonation and decreased potential B and T cell interaction and lower nuclear density in COVID-19 patients. This occurred independent of the local viral levels. The changes in PP demonstrate that the ability to mount an intestinal immune response is compromised in severe COVID-19, which could contribute to observed dysbiosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peyer's Patches / Atrophy / Germinal Center / COVID-19 / Intestinal Mucosa Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.838328

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Peyer's Patches / Atrophy / Germinal Center / COVID-19 / Intestinal Mucosa Type of study: Prognostic study Limits: Humans Language: English Journal: Front Immunol Year: 2022 Document Type: Article Affiliation country: Fimmu.2022.838328