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A Review of the Potential Roles of Antioxidant and Anti-Inflammatory Pharmacological Approaches for the Management of Mild-to-Moderate Symptomatic COVID-19.
Fazio, Serafino; Affuso, Flora; Bellavite, Paolo.
  • Fazio S; Department of Internal Medicine (retired professor), Medical School University Federico II, Naples, Italy.
  • Affuso F; Independent Researcher, Lecce, Italy.
  • Bellavite P; Physiopathology Chair, Homeopathic Medical School of Verona, Verona, Italy.
Med Sci Monit ; 28: e936292, 2022 Mar 08.
Article in English | MEDLINE | ID: covidwho-1732487
ABSTRACT
In the past 2 years, the coronavirus disease 2019 (COVID-19) pandemic has driven investigational studies and controlled clinical trials on antiviral treatments and vaccines that have undergone regulatory approval. Now that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants may become endemic over time, there remains a need to identify drugs that treat the symptoms of COVID-19 and prevent progression toward severe cases, hospitalization, and death. Understanding the molecular mechanisms of SARS-CoV-2 infection is extremely important for the development of effective therapies against COVID-19. This review outlines the key pathways involved in the host response to SARS-CoV-2 infection and discusses the potential role of antioxidant and anti-inflammatory pharmacological approaches for the management of early mild-to-moderate COVID-19, using the examples of combined indomethacin, low-dose aspirin, omeprazole, hesperidin, quercetin, and vitamin C. The pharmacological targets of these substances are described here for their possible synergism in counteracting SARS-CoV-2 replication and progression of the infection from the upper respiratory airways to the blood, avoiding vascular complications and cytokine and bradykinin storms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host Microbial Interactions / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: MSM.936292

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Host Microbial Interactions / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Experimental Studies / Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Med Sci Monit Journal subject: Medicine Year: 2022 Document Type: Article Affiliation country: MSM.936292