Evidence of autoantibodies in hospitalized COVID-19 patients
Biochimica Clinica
; 45(SUPPL 2):S77, 2022.
Article
in English
| EMBASE | ID: covidwho-1733374
ABSTRACT
Recent studies highlight the evidence of autoantibodies in patients affected by Corona Virus Disease-2019 (COVID-19). We evaluated whether severe acute respiratory syndrome (SARS-CoV-2) stimulates autoantibody production and contributes to autoimmunity activation. We enrolled 40 adult patients (66.8 years mean age) admitted to Alessandria hospital between March and April 2020 with a confirmed COVID-19 diagnosis by real-time polymerase chain reaction (RT-PCR) and no previously clinical record of autoimmune disease. 40 blood donors were analyzed for the same markers and considered as healthy controls. All hospitalized patients had high levels of common inflammatory markers, such as C Reactive Protein, Lactate Dehydrogenase, ferritin and creatinine. Interleukin-6 concentrations were also increased, supporting the major role of this interleukin during COVID-19 infection. Lymphocytes number was generally lower compared to healthy individuals. All the patients were also screened for the most common autoantibodies. We found a significant prevalence of ANA (57,5%), ANCA (25%), and ASCA IgA (25%) antibodies in COVID-19 patients compared to healthy controls. We observed that patients having a de novo autoimmune response had the worst acute viral disease prognosis and outcome. Our results sustain the hypothesis that COVID-19 virus might break the body tolerance to itself and stimulate autoimmune responses, suggesting they were directly related to viral infection, instead of being a preexisting condition. The observed increase of autoantibodies remained stable in six-month follow-up of COVID-19 patients. Moreover, preliminary data indicate in a few patients the apparence of clinical manifestations suggestive of autoimmune disease onset. More study will be needed to find out whether these autoimmune profiles persist in COVID-19 affected patients.
autoantibody; C reactive protein; creatinine; endogenous compound; ferritin; immunoglobulin A; interleukin 6; interleukin derivative; lactate dehydrogenase; neutrophil cytoplasmic antibody; adult; autoimmune disease; autoimmunity; blood donor; clinical article; conference abstract; controlled study; coronavirus disease 2019; female; ferritin blood level; follow up; gene expression; hospital patient; human; lymphocyte count; male; nonhuman; outcome assessment; preliminary data; prevalence; prognosis; protein function; real time polymerase chain reaction; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2
Search on Google
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Biochimica Clinica
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS