Proline-specific peptidase activities (DPP4, PRCP, FAP and PREP) in plasma of hospitalized COVID-19 patients.
Clin Chim Acta
; 531: 4-11, 2022 Jun 01.
Article
in English
| MEDLINE | ID: covidwho-1734231
ABSTRACT
BACKGROUND:
COVID-19 patients experience several features of dysregulated immune system observed in sepsis. We previously showed a dysregulation of several proline-selective peptidases such as dipeptidyl peptidase 4 (DPP4), fibroblast activation protein alpha (FAP), prolyl oligopeptidase (PREP) and prolylcarboxypeptidase (PRCP) in sepsis. In this study, we investigated whether these peptidases are similarly dysregulated in hospitalized COVID-19 patients.METHODS:
Fifty-six hospitalized COVID-19 patients and 32 healthy controls were included. Enzymatic activities of DPP4, FAP, PREP and PRCP were measured in samples collected shortly after hospital admission and in longitudinal follow-up samples.RESULTS:
Compared to healthy controls, both DPP4 and FAP activities were significantly lower in COVID-19 patients at hospital admission and FAP activity further decreased significantly in the first week of hospitalization. While PRCP activity remained unchanged, PREP activity was significantly increased in COVID-19 patients at hospitalization and further increased during hospital stay and stayed elevated until the day of discharge.CONCLUSION:
The changes in activities of proline-selective peptidases in plasma are very similar in COVID-19 and septic shock patients. The pronounced decrease in FAP activity deserves further investigation, both from a pathophysiological viewpoint and as its utility as a part of a biomarker panel.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Shock, Septic
/
COVID-19
Type of study:
Cohort study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Chim Acta
Year:
2022
Document Type:
Article
Affiliation country:
J.cca.2022.03.005
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